EFFECT OF HEXANIC AND ALCOHOLIC EXTRACTS OF FENUGREEK SEED IN MALE DIABETIC RATS

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ABEDINZADE MAHMOOD; NIKOKAR IRAJ; NASRI SIMA; JAMAL OMIDI MASOME; NURSABAGHI FARZAD

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Journal: Zahedan Journal of Research in Medical Sciences Year:2013 | Volume:15 | Issue:6 Page(s): 50-53

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Title

EFFECT OF HEXANIC AND ALCOHOLIC EXTRACTS OF FENUGREEK SEED IN MALE DIABETIC RATS

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Keywords

DIABETES COMPLICATIONS

TRIGONELLA

CHOLESTEROL

BLOOD GLUCOSE

Abstract

Background: Diabetes mellitus is recognized with severe complications. Many herbal medicines have been recommended for treatment of diabetes problem. In this study, the effect of hexanic and alcoholic extracts of fenugreek (Trigonella-foenum graecum) on serum parameters was investigated in normal and streptozotocin-induced diabetic rats.Materials and Methods: This experimental study was carried out in 2011 at paramedical school of Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gram) were divided into six groups: control, type 1 diabetic, and 2 diabetic groups that receive alcoholic extract and 2 groups receive hexanic extract of fenugreek (100, 200 mg/kg body weight) intraperitonealy for 28 days. For diabetes induction, streptozotocin (60 mg/kg/ intraperitonealy) was used. BLOOD GLUCOSE, total CHOLESTEROL, triglyceride (TG), urea, creatinine, uric acid, AST and ALT level Results: fenugreek extract inhibit weight loss especially in diabetic groups that receive hexanic extract (p=0.006). BLOOD GLUCOSE, total CHOLESTEROL, TG, urea, creatin in, uric acid, AST and ALT level was reduced significantly in diabetics groups that receive fenugreek extract (p=0.001). This effect was stronger in groups that receive Hexanic extract Conclusion: Fenugreek is a good candidate for reduction of diabetic complications.

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APA: Copy

ABEDINZADE, MAHMOOD, NIKOKAR, IRAJ, NASRI, SIMA, JAMAL OMIDI, MASOME, & NURSABAGHI, FARZAD. (2013). EFFECT OF HEXANIC AND ALCOHOLIC EXTRACTS OF FENUGREEK SEED IN MALE DIABETIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(6), 50-53. SID. https://sid.ir/paper/616371/en

Vancouver: Copy

ABEDINZADE MAHMOOD, NIKOKAR IRAJ, NASRI SIMA, JAMAL OMIDI MASOME, NURSABAGHI FARZAD. EFFECT OF HEXANIC AND ALCOHOLIC EXTRACTS OF FENUGREEK SEED IN MALE DIABETIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(6):50-53. Available from: https://sid.ir/paper/616371/en

IEEE: Copy

MAHMOOD ABEDINZADE, IRAJ NIKOKAR, SIMA NASRI, MASOME JAMAL OMIDI, and FARZAD NURSABAGHI, “EFFECT OF HEXANIC AND ALCOHOLIC EXTRACTS OF FENUGREEK SEED IN MALE DIABETIC RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 6, pp. 50–53, 2013, [Online]. Available: https://sid.ir/paper/616371/en

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