MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARIBORZI MOHAMMADREZA; FARAHMAND FATEMEH; FALLAHI GHOLAMHOSEIN; ASHTYANI MOHAMMADTAGHI; HASHEMI MASUMEH; KIUMARSI AZADEH; ALLAMEH MOHAMMAD MAHDY

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: GOVARESH JOURNAL Year:2014 | Volume:19 | Issue:2 Page(s): 143-145

Download Full-Text

View:

317

Download:

101

Cites:

Information Journal Paper

Title

MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA

Author(s)

Keywords

TNF-α

EXTRAHEPATIC BILIARY ATRESIA

CHOLESTASIS

HEPATITIS

Abstract

Background: Most diagnostic tests for biliary atresia (BA) are invasive. This study evaluates the sensitivity and specificity of serum tumor necrosis factor-a (TNF-a) for diagnosing extra hepatic biliary duct atresia (EHBA) in infants.Materials and Methods: Infants with CHOLESTASIS who were admitted to Children′s Medical Center Hospital were evaluated. A total of 50 infants (20 with EHBA and 30 non-EHBA) were included in this study. We evaluated the definite cause of CHOLESTASIS. Intra-operative cholangiography and, if possible, Kasai portoenterostomy were performed in infants with high suspicion for EHBA. Upon admission and prior to surgical intervention, infants had their serum TNF-a levels measured by ELISA. We compared the mean TNF-a level between the two groups, in addition to the sensitivity and specificity of serum TNF-α for diagnosis of EHBA.Results: This study enrolled 28 (56%) male and 22 (44%) female infants. Infants'' mean age was 2.87 months in the EHBA group and 2.6 months in the non-EHBA group. Sensitivity of serum TNF was 60% and its specificity was 76.66% for predicting EHBA. The positive predictive value was calculated as 63.1%, the negative predictive value was 74.1%, and accuracy was 70%. There was a significantly higher mean serum TNF-a level in the EHBA group (220 pg/ml) compared to the non-EHBA group (79.8 pg/ml, p=0.023). Serum TNF-a cut off point for determining EHBA from non-EHBA was calculated as 80 pg/ml. Mean serum TNF-a in males (171.28 pg/ml) was more than females (90.80 pg/ml).Conclusion: There was a significantly higher mean serum TNF-a level in the EHBA group than the non-EHBA group. Serum TNF-α could be a proper test that has comparatively good sensitivity, specificity, positive predictive value and negative predictive value for predicting EHBA.

Cites

No record.

References

No record.

Cite

APA: Copy

FARIBORZI, MOHAMMADREZA, FARAHMAND, FATEMEH, FALLAHI, GHOLAMHOSEIN, ASHTYANI, MOHAMMADTAGHI, HASHEMI, MASUMEH, KIUMARSI, AZADEH, & ALLAMEH, MOHAMMAD MAHDY. (2014). MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA. GOVARESH JOURNAL, 19(2), 143-145. SID. https://sid.ir/paper/629169/en

Vancouver: Copy

FARIBORZI MOHAMMADREZA, FARAHMAND FATEMEH, FALLAHI GHOLAMHOSEIN, ASHTYANI MOHAMMADTAGHI, HASHEMI MASUMEH, KIUMARSI AZADEH, ALLAMEH MOHAMMAD MAHDY. MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA. GOVARESH JOURNAL[Internet]. 2014;19(2):143-145. Available from: https://sid.ir/paper/629169/en

IEEE: Copy

MOHAMMADREZA FARIBORZI, FATEMEH FARAHMAND, GHOLAMHOSEIN FALLAHI, MOHAMMADTAGHI ASHTYANI, MASUMEH HASHEMI, AZADEH KIUMARSI, and MOHAMMAD MAHDY ALLAMEH, “MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA,” GOVARESH JOURNAL, vol. 19, no. 2, pp. 143–145, 2014, [Online]. Available: https://sid.ir/paper/629169/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops