مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

292
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

213
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EFFECT OF METHYLSULFONYLMETHANE PRETREATMENT ON ACETA-MINOPHEN INDUCED HEPATOTOXICITY IN RATS

Pages

  896-900

Abstract

 Objective(s): METHYLSULFONYLMETHANE (MSM) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. In this study the effect of MSM pretreatment on ACETAMINOPHEN induced liver damage was investigated.Materials and Methods: Male Sprague Dawley rats were pretreated with 100 mg/kg MSM for one week. On day seven rats were received ACETAMINOPHEN (850 mg/kg, intraperitoneal). Twenty-four hours later, blood samples were taken to determine serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Tissue samples of liver were also taken for the determination of the levels of malondialdehyde (MDA); total glutathione (GSH), superoxide dismutase (SOD), and myeloperoxidase (MPO) activity together with histopathological observations.Results: High dose of ACETAMINOPHEN administration caused a significant decrease in the GSH level of the liver tissue, which was accompanied with a decrease in SOD activity and increases in tissue MDA level and MPO activity. Serum ALT, AST levels were also found elevated in the ACETAMINOPHEN-treated group. Pretreatment with MSM for one week was significantly attenuated all of these biochemical indices.Conclusion: Our findings suggest that MSM pretreatment could alleviate hepatic injury induced by ACETAMINOPHEN intoxication, may be through its sulfur donating and antioxidant effects.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    BOHLOOLI, SHAHAB, MOHAMMADI, SADOLLAH, AMIRSHAHROKHI, KEYVAN, MIRZANEJAD ASL, HAFEZ, YOSEFI, MOHAMMAD, MOHAMMADI NEI, AMIR, & CHINIFROUSH, MIR MEHDI. (2013). EFFECT OF METHYLSULFONYLMETHANE PRETREATMENT ON ACETA-MINOPHEN INDUCED HEPATOTOXICITY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(8), 896-900. SID. https://sid.ir/paper/629220/en

    Vancouver: Copy

    BOHLOOLI SHAHAB, MOHAMMADI SADOLLAH, AMIRSHAHROKHI KEYVAN, MIRZANEJAD ASL HAFEZ, YOSEFI MOHAMMAD, MOHAMMADI NEI AMIR, CHINIFROUSH MIR MEHDI. EFFECT OF METHYLSULFONYLMETHANE PRETREATMENT ON ACETA-MINOPHEN INDUCED HEPATOTOXICITY IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(8):896-900. Available from: https://sid.ir/paper/629220/en

    IEEE: Copy

    SHAHAB BOHLOOLI, SADOLLAH MOHAMMADI, KEYVAN AMIRSHAHROKHI, HAFEZ MIRZANEJAD ASL, MOHAMMAD YOSEFI, AMIR MOHAMMADI NEI, and MIR MEHDI CHINIFROUSH, “EFFECT OF METHYLSULFONYLMETHANE PRETREATMENT ON ACETA-MINOPHEN INDUCED HEPATOTOXICITY IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 8, pp. 896–900, 2013, [Online]. Available: https://sid.ir/paper/629220/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button