PENTOXIFYLLINE PROTECTS THE RAT LIVER AGAINST FIBROSIS AND APOPTOSIS INDUCED BY ACUTE ADMINISTRATION OF 3, 4- METHYLENEDIOXYMETHAMPHETAMINE (MDMA OR ECSTASY)

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MOVASSAGHI SHABNAM; NADIA SHARIFI ZAHRA; MOHAMMADZADEH FARZANEH; SOLEIMANI MANSOOREH

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:8 Page(s): 922-927

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Title

PENTOXIFYLLINE PROTECTS THE RAT LIVER AGAINST FIBROSIS AND APOPTOSIS INDUCED BY ACUTE ADMINISTRATION OF 3, 4- METHYLENEDIOXYMETHAMPHETAMINE (MDMA OR ECSTASY)

Author(s)

MOVASSAGHI SHABNAM | NADIA SHARIFI ZAHRA | MOHAMMADZADEH FARZANEH | SOLEIMANI MANSOOREH | Issue Writer Certificate

Keywords

APOPTOSIS

FIBROSIS

LIVER

MDMA

PENTOXIFYLLINE

Abstract

Objective(s): 3, 4-Methylenedioxymethamphetamine (MDMA) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce APOPTOSIS in LIVER cells. The present study aimed to investigate the effects of PENTOXIFYLLINE (PTX) on LIVER damage induced by acute administration of MDMA in Wistar rat.Materials and Methods: Animals were administered with saline or MDMA (7.5 mg/kg, IP) 3 times with 2 hr intervals. PTX (200 mg kg, IP), was administered simultaneously with last injection of MDMA in experimental group.Results: The concomitant administration of PENTOXIFYLLINE and MDMA decreased LIVER injury including APOPTOSIS, FIBROSIS and hepatocytes damages.Conclusion: Our results showed for the first time that PTX treatment diminishes the extent of APOPTOSIS and FIBROSIS caused by MDMA in rat LIVER.

Cites

RITALIN ABUSE AND ITS COMPLICATIONS (REVIEW ARTICLE)

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APA: Copy

MOVASSAGHI, SHABNAM, NADIA SHARIFI, ZAHRA, MOHAMMADZADEH, FARZANEH, & SOLEIMANI, MANSOOREH. (2013). PENTOXIFYLLINE PROTECTS THE RAT LIVER AGAINST FIBROSIS AND APOPTOSIS INDUCED BY ACUTE ADMINISTRATION OF 3, 4- METHYLENEDIOXYMETHAMPHETAMINE (MDMA OR ECSTASY). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(8), 922-927. SID. https://sid.ir/paper/629225/en

Vancouver: Copy

MOVASSAGHI SHABNAM, NADIA SHARIFI ZAHRA, MOHAMMADZADEH FARZANEH, SOLEIMANI MANSOOREH. PENTOXIFYLLINE PROTECTS THE RAT LIVER AGAINST FIBROSIS AND APOPTOSIS INDUCED BY ACUTE ADMINISTRATION OF 3, 4- METHYLENEDIOXYMETHAMPHETAMINE (MDMA OR ECSTASY). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(8):922-927. Available from: https://sid.ir/paper/629225/en

IEEE: Copy

SHABNAM MOVASSAGHI, ZAHRA NADIA SHARIFI, FARZANEH MOHAMMADZADEH, and MANSOOREH SOLEIMANI, “PENTOXIFYLLINE PROTECTS THE RAT LIVER AGAINST FIBROSIS AND APOPTOSIS INDUCED BY ACUTE ADMINISTRATION OF 3, 4- METHYLENEDIOXYMETHAMPHETAMINE (MDMA OR ECSTASY),” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 8, pp. 922–927, 2013, [Online]. Available: https://sid.ir/paper/629225/en

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