مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

346
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

264
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

THE EFFECT OF PLATELET RICH PLASMA ON CHONDROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLS IN TRANSWELL CULTURE

Pages

  1163-1169

Abstract

 Objective (s): PLATELET-RICH PLASMA (PRP) has recently emerged as a promising strategy in regenerative medicine due to its multiple endogenous growth factors. Little is known about the role of PRP as a promoter in chondrogenesis of human adipose derived stem cells (hADSCs). The aim of this study was to determine whether PRP may be considered as a natural and easy achievable source of growth factors to promote the chondrogenic differentiation of hADSCs in TRANSWELL CULTURE.Materials and Methods: Biochemical, immunohistological and molecular assays were used to evaluate the effect of different concentrations (5%, 10%, and 15%) of PRP on chondrogenic differentiation of hADSCs in TRANSWELL CULTURE.Results: The cells in the presence of 10% PRP produced markedly higher amounts of GAG and DNA, in comparison to the control group. PRP also increased chondrogenic markers in these cells, such as sox-9, aggrecan and collagen type II. A high expression level of collagen type X as a hypertrophic marker was observed in cartilage produced by using either PRP or TGF-b1.Conclusion: Our findings indicate that autologous PRP at an optimum concentration had beneficial effects on differentiation of hADSCs in TRANSWELL CULTURE. Further, in vivo studies are necessary to fully define the clinical implications of PRP.

Cites

References

  • No record.

    • Cite

    APA: Copy

    MARDANI, MOHAMMAD, KABIRI, AZADEH, ESFANDIARI, EBRAHIM, ESMAEILI, ABOLGHASEM, POURAZAR, ABBASALI, ANSAR, MALEKMASSOUD, & HASHEMIBENI, BATOOL. (2013). THE EFFECT OF PLATELET RICH PLASMA ON CHONDROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLS IN TRANSWELL CULTURE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(11), 1163-1169. SID. https://sid.ir/paper/629232/en

    Vancouver: Copy

    MARDANI MOHAMMAD, KABIRI AZADEH, ESFANDIARI EBRAHIM, ESMAEILI ABOLGHASEM, POURAZAR ABBASALI, ANSAR MALEKMASSOUD, HASHEMIBENI BATOOL. THE EFFECT OF PLATELET RICH PLASMA ON CHONDROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLS IN TRANSWELL CULTURE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(11):1163-1169. Available from: https://sid.ir/paper/629232/en

    IEEE: Copy

    MOHAMMAD MARDANI, AZADEH KABIRI, EBRAHIM ESFANDIARI, ABOLGHASEM ESMAEILI, ABBASALI POURAZAR, MALEKMASSOUD ANSAR, and BATOOL HASHEMIBENI, “THE EFFECT OF PLATELET RICH PLASMA ON CHONDROGENIC DIFFERENTIATION OF HUMAN ADIPOSE DERIVED STEM CELLS IN TRANSWELL CULTURE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 11, pp. 1163–1169, 2013, [Online]. Available: https://sid.ir/paper/629232/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button