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Information Journal Paper

Title

DISTRIBUTION AND PROTECTIVE ROLE OF HLAB40 IN IRANIAN PATIENTS WITH KAWASAKI DISEASE; A REPORT FROM SOUTHERN IRAN

Pages

  359-364

Abstract

 Objective: KAWASAKI DISEASE (KD) clinically presents as a systemic vasculitis syndrome with significant cardiovascular involvement. With different incidence among different ethnic groups, the role of certain HUMAN LEUKOCYTE ANTIGENS and their products has been considered as a crucial predisposing factor in the immune responses in this disease.Methods: We determined the distribution of HUMAN LEUKOCYTE ANTIGENS type B for 90 Iranian patients with KAWASAKI DISEASE in order to evaluate a possible association between these antigens and this disease in our area. We used the polymerase chain reaction (PCR) sequence specific primers (PCR-SSP) technique for antigen typing. Distribution of these antigens for 89 healthy Iranians used as control.Findings: While 7 (3.9%) of our patients were positive for human leukocyte antigen type B 40*, there were 18 (10.1%) subjects from the control group who had this antigen with statistically significant difference between patients and control group (CI=95%, RR=1.15 and P=0.02). Data were analyzed by Pearson chi-square test and Fisher's exact test. SPSS version 15 was used for statistical analysis and a P value less than 0.05 considered statistically significant Conclusion: The presence of higher frequency of allele type-B40* in the control group may represent a protective role for this antigen with resultant decreased susceptibility to KD in our area.

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    APA: Copy

    AJAMI, GHOLAMHOSSEIN, AFLAKI, KHASHAYAR, ALYASIN, SOHEILA, GHARESI FARD, BEHROUZ, BORZOUEE, MOHAMMAD, & AMOOZGAR, HAMID. (2014). DISTRIBUTION AND PROTECTIVE ROLE OF HLAB40 IN IRANIAN PATIENTS WITH KAWASAKI DISEASE; A REPORT FROM SOUTHERN IRAN. IRANIAN JOURNAL OF PEDIATRICS, 24(4), 359-364. SID. https://sid.ir/paper/629331/en

    Vancouver: Copy

    AJAMI GHOLAMHOSSEIN, AFLAKI KHASHAYAR, ALYASIN SOHEILA, GHARESI FARD BEHROUZ, BORZOUEE MOHAMMAD, AMOOZGAR HAMID. DISTRIBUTION AND PROTECTIVE ROLE OF HLAB40 IN IRANIAN PATIENTS WITH KAWASAKI DISEASE; A REPORT FROM SOUTHERN IRAN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2014;24(4):359-364. Available from: https://sid.ir/paper/629331/en

    IEEE: Copy

    GHOLAMHOSSEIN AJAMI, KHASHAYAR AFLAKI, SOHEILA ALYASIN, BEHROUZ GHARESI FARD, MOHAMMAD BORZOUEE, and HAMID AMOOZGAR, “DISTRIBUTION AND PROTECTIVE ROLE OF HLAB40 IN IRANIAN PATIENTS WITH KAWASAKI DISEASE; A REPORT FROM SOUTHERN IRAN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 24, no. 4, pp. 359–364, 2014, [Online]. Available: https://sid.ir/paper/629331/en

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