SIGNIFICANCE OF MICRORNA TARGETED ESTROGEN RECEPTOR IN MALE FERTILITY

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ABHARI ALIREZA; ZARGHAMI NOSRATOLLAH; SHAHNAZI VAHIDEH; BARZEGARI ABOLFAZL; FARZADI LAYA; KARAMI HADI; ZUNUNI VAHED SEPIDEH; NOURI MOHAMMAD

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:2 Page(s): 81-86

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Title

SIGNIFICANCE OF MICRORNA TARGETED ESTROGEN RECEPTOR IN MALE FERTILITY

Author(s)

Keywords

FERTILITY

HAS-MIR-100

HAS-LET-7B

MICRORNA

Abstract

Objective(s): Estrogen receptor-alpha (ERa) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koa) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that MICRORNA (miRNA) mir-100 and let-7b were predicted to target ERa gene. MiRNA are small, endogenous, single stranded RNA molecules that regulate gene expression and have been implicated in various disease states. It has been proved that some miRNAs expression is tissue- and disease-specific, giving potential for identifying miRNAs as a diagnostic tool.Materials and Methods: In this study, the change in the expression levels of mir-100, let-7b and ERa expression levels were evaluated in oligospermic infertile patients (n=43) compared to control fertile subjects (n=43). After washing and separating sperms, total RNA was isolated and then cDNA was synthesized. The expression levels of mir-100 and let-7b and ERa were evaluated by real time PCR.Results: Mir-100, let-7b levels were significantly higher than those in control group (P=0.008 and P=0.009, respectively). We have found that, ERa level was significantly decreased in comparison with normal group (P<0.0001).Conclusion: Changes in mir-100, let-7b and ERa expression levels in oligospermic patients may be associated with the susceptibility and progression of inFERTILITY. The results of this study indicate that miRNA can have a key role in spermatogenesis and might have a diagnostic and prognostic value in men inFERTILITY.

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APA: Copy

ABHARI, ALIREZA, ZARGHAMI, NOSRATOLLAH, SHAHNAZI, VAHIDEH, BARZEGARI, ABOLFAZL, FARZADI, LAYA, KARAMI, HADI, ZUNUNI VAHED, SEPIDEH, & NOURI, MOHAMMAD. (2014). SIGNIFICANCE OF MICRORNA TARGETED ESTROGEN RECEPTOR IN MALE FERTILITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(2), 81-86. SID. https://sid.ir/paper/629407/en

Vancouver: Copy

ABHARI ALIREZA, ZARGHAMI NOSRATOLLAH, SHAHNAZI VAHIDEH, BARZEGARI ABOLFAZL, FARZADI LAYA, KARAMI HADI, ZUNUNI VAHED SEPIDEH, NOURI MOHAMMAD. SIGNIFICANCE OF MICRORNA TARGETED ESTROGEN RECEPTOR IN MALE FERTILITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(2):81-86. Available from: https://sid.ir/paper/629407/en

IEEE: Copy

ALIREZA ABHARI, NOSRATOLLAH ZARGHAMI, VAHIDEH SHAHNAZI, ABOLFAZL BARZEGARI, LAYA FARZADI, HADI KARAMI, SEPIDEH ZUNUNI VAHED, and MOHAMMAD NOURI, “SIGNIFICANCE OF MICRORNA TARGETED ESTROGEN RECEPTOR IN MALE FERTILITY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 2, pp. 81–86, 2014, [Online]. Available: https://sid.ir/paper/629407/en

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