EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY

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BOSKABADI HASSAN; MAAMOURI GHOLAMALI; TAVAKOL AFSHARI JALIL; MAFINEJAD SHAHIN; HOSSEINI GOLKOO; MOSTAFAVI TOROGHI HESAM; SABER HAMIDREZA; GHAYOUR MOBARHAN MAJID; FERNS GORDON

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Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:12 Page(s): 1232-1237

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Title

EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY

Author(s)

Keywords

INFECTION

INTERLEUKIN-6

INTERLEUKIN-8

INTERLEUKIN-10

NEWBORN

SEPSIS

Abstract

Objective (s): Bacterial INFECTION contributes substantially to neonatal morbidity and mortality. Early diagnosis of neonatal SEPSIS is difficult because clinical signs are non-specific. We have evaluated serum IL-6, 8 and 10 as potential early diagnostic markers of neonatal INFECTION and their relationship to mortality rate and poor prognosis.Materials and Methods: A total of 84 infants, aged ≥ 72 hr were enrolled in this prospective case-control trial. The case group (n=41) included babies with clinical and laboratory findings compatible with SEPSIS and/or positive blood or cerebrospinal fluid cultures. The control group (n=43) included healthy infants. IL-6, 8 and 10 were measured for all infants. Receiver-operating characteristic (ROC) curves were used for the determination of thresholds.Results: Statistically significant differences were observed between control and case groups for serum median level of IL-6, 8 and 10 (P<0.001). IL-6 cut-off values of 10.85 Pg/ml for discriminating between cases and controls and 78.2 Pg/ml for predicting mortality are suggested. IL-8 at a cut-off value of 60.05 Pg/ml was valuable for differentiation of definite versus indefinite INFECTION.Conclusion: Evaluating the IL-6, 8 and 10 simultaneously, could improve the sensitivity and specificity of early diagnosis of the neonatal SEPSIS. Regarding our results, interleukin 6 had the greatest value for predicting INFECTION and possible mortality, whereas IL-8 was valuable for diagnosing definitive INFECTION.

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بررسی تجویز سفوتاکسیم در مقایسه با آمپی سیلین در مادران باردار دچار پارگی زودرس کیسه آب بر بروز عفونت در نوزادان

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APA: Copy

BOSKABADI, HASSAN, MAAMOURI, GHOLAMALI, TAVAKOL AFSHARI, JALIL, MAFINEJAD, SHAHIN, HOSSEINI, GOLKOO, MOSTAFAVI TOROGHI, HESAM, SABER, HAMIDREZA, GHAYOUR MOBARHAN, MAJID, & FERNS, GORDON. (2013). EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1232-1237. SID. https://sid.ir/paper/629461/en

Vancouver: Copy

BOSKABADI HASSAN, MAAMOURI GHOLAMALI, TAVAKOL AFSHARI JALIL, MAFINEJAD SHAHIN, HOSSEINI GOLKOO, MOSTAFAVI TOROGHI HESAM, SABER HAMIDREZA, GHAYOUR MOBARHAN MAJID, FERNS GORDON. EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(12):1232-1237. Available from: https://sid.ir/paper/629461/en

IEEE: Copy

HASSAN BOSKABADI, GHOLAMALI MAAMOURI, JALIL TAVAKOL AFSHARI, SHAHIN MAFINEJAD, GOLKOO HOSSEINI, HESAM MOSTAFAVI TOROGHI, HAMIDREZA SABER, MAJID GHAYOUR MOBARHAN, and GORDON FERNS, “EVALUATION OF SERUM INTERLEUKINS-6, 8 AND 10 LEVELS AS DIAGNOSTIC MARKERS OF NEONATAL INFECTION AND POSSIBILITY OF MORTALITY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 12, pp. 1232–1237, 2013, [Online]. Available: https://sid.ir/paper/629461/en

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