ABSENCE OF ASSOCIATION BETWEEN -1131T>C POLYMORPHISM IN THE APOLIPOPROTEIN APOA5 GENE AND PEDIATRIC METABOLIC SYNDROME (SHORT COMMUNICATION)

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FATEMI SAYEDEH GHAZALEH; EMADI BAYGI MODJTABA; NIKPOUR PARVANEH; KELISHADI ROYA; HASHEMIPOUR MAHIN

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Journal: Iranian Journal of Pediatrics Year:2014 | Volume:24 | Issue:3 Page(s): 319-322

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Title

ABSENCE OF ASSOCIATION BETWEEN -1131T>C POLYMORPHISM IN THE APOLIPOPROTEIN APOA5 GENE AND PEDIATRIC METABOLIC SYNDROME (SHORT COMMUNICATION)

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Keywords

APOLIPOPROTEIN A5 GENE

METABOLIC SYNDROME

CHILDREN

ADOLESCENTS

TRIGLYCERIDE

CHOLESTEROL

Abstract

Objective: In the present study, we evaluated the association of rs662799 variant of the APOA5 gene with METABOLIC SYNDROME (MetS) in a sample of CHILDREN and ADOLESCENTS from Isfahan.Methods: This case control study comprised 50 cases of MetS and 50 controls. Mismatched polymerase chain reaction–restriction fragment length polymorphism (mPCR-RFLP) was used to genotype-1131T>C polymorphism.Findings: No significant association was documented for APOA5 genotypes with the measured laboratory parameters for CC, CT, and TT genotypes in the two groups studied. By logistic regression using a dominant model, the odds ratio (95% confidence interval0 for the MetS was 0.38 (0.139–1.0350 and 0.29 (0.08–1.071 for the unadjusted and adjusted models, respectively.Conclusion: This study suggests that among studied CHILDREN and ADOLESCENTS,-1131T>C polymorphism in the APOA5 gene may not be a major contributor to the MetS risk..

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APA: Copy

FATEMI, SAYEDEH GHAZALEH, EMADI BAYGI, MODJTABA, NIKPOUR, PARVANEH, KELISHADI, ROYA, & HASHEMIPOUR, MAHIN. (2014). ABSENCE OF ASSOCIATION BETWEEN -1131T>C POLYMORPHISM IN THE APOLIPOPROTEIN APOA5 GENE AND PEDIATRIC METABOLIC SYNDROME (SHORT COMMUNICATION). IRANIAN JOURNAL OF PEDIATRICS, 24(3), 319-322. SID. https://sid.ir/paper/630156/en

Vancouver: Copy

FATEMI SAYEDEH GHAZALEH, EMADI BAYGI MODJTABA, NIKPOUR PARVANEH, KELISHADI ROYA, HASHEMIPOUR MAHIN. ABSENCE OF ASSOCIATION BETWEEN -1131T>C POLYMORPHISM IN THE APOLIPOPROTEIN APOA5 GENE AND PEDIATRIC METABOLIC SYNDROME (SHORT COMMUNICATION). IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2014;24(3):319-322. Available from: https://sid.ir/paper/630156/en

IEEE: Copy

SAYEDEH GHAZALEH FATEMI, MODJTABA EMADI BAYGI, PARVANEH NIKPOUR, ROYA KELISHADI, and MAHIN HASHEMIPOUR, “ABSENCE OF ASSOCIATION BETWEEN -1131T>C POLYMORPHISM IN THE APOLIPOPROTEIN APOA5 GENE AND PEDIATRIC METABOLIC SYNDROME (SHORT COMMUNICATION),” IRANIAN JOURNAL OF PEDIATRICS, vol. 24, no. 3, pp. 319–322, 2014, [Online]. Available: https://sid.ir/paper/630156/en

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