AUTONOMOUS DRUG-ENCAPSULATED NANOPARTICLES: TOWARDS A NOVEL NON-INVASIVE APPROACH TO PREVENT ATHEROSCLEROSIS

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ROWHANIMANESH ALIREZA; AKBARZADEH TOTONCHI MOHAMMAD REZA

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL PHYSICS Year:2013 | Volume:10 | Issue:3 Page(s): 118-132

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Information Journal Paper

Title

AUTONOMOUS DRUG-ENCAPSULATED NANOPARTICLES: TOWARDS A NOVEL NON-INVASIVE APPROACH TO PREVENT ATHEROSCLEROSIS

Author(s)

ROWHANIMANESH ALIREZA | AKBARZADEH TOTONCHI MOHAMMAD REZA | Issue Writer Certificate

Keywords

ATHEROSCLEROSIS

LOW DENSITY LIPOPROTEIN

NONLINEAR CONTROL

SWARM CONTROL

NANOPARTICLES

Abstract

ntroductionThis paper proposes the concept of autonomous drug-encapsulated nanoparticle (ADENP) as a novel noninvasive approach to prevent ATHEROSCLEROSIS. ADENP consists of three simple units of sensor, controller (computing), and actuator. The hardware complexity of ADENP is much lower than most of the nanorobots, while the performance is maintained by the synergism in the swarm architecture.Materials and MethodsSince high accumulation of LOW DENSITY LIPOPROTEIN (LDL) macromolecules within the arterial wall plays a critical role in the initiation and development of atherosclerotic plaques, the task of the swarm of ADENPs is autonomous feedback control of LDL level in the interior of the arterial wall. In this study, we consider two specific types of ADENPs with distinguishing capabilities. The performance of each type is evaluated and compared on a well-known mathematical model of the arterial wall through computer simulation.ResultsSimulation results demonstrate that the proposed approach can successfully reduce the LDL level to a desired value in the arterial wall of a patient with very high LDL level that is corresponding to the highest rates of cardiovascular disease events. Moreover, it is shown that ADENP is capable of distinguishing between healthy and unhealthy arterial walls to reduce the drug side effects.ConclusionThe proposed approach is a promising autonomous non-invasive method to prevent and treat complex diseases such as ATHEROSCLEROSIS.

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APA: Copy

ROWHANIMANESH, ALIREZA, & AKBARZADEH TOTONCHI, MOHAMMAD REZA. (2013). AUTONOMOUS DRUG-ENCAPSULATED NANOPARTICLES: TOWARDS A NOVEL NON-INVASIVE APPROACH TO PREVENT ATHEROSCLEROSIS. IRANIAN JOURNAL OF MEDICAL PHYSICS, 10(3), 118-132. SID. https://sid.ir/paper/630484/en

Vancouver: Copy

ROWHANIMANESH ALIREZA, AKBARZADEH TOTONCHI MOHAMMAD REZA. AUTONOMOUS DRUG-ENCAPSULATED NANOPARTICLES: TOWARDS A NOVEL NON-INVASIVE APPROACH TO PREVENT ATHEROSCLEROSIS. IRANIAN JOURNAL OF MEDICAL PHYSICS[Internet]. 2013;10(3):118-132. Available from: https://sid.ir/paper/630484/en

IEEE: Copy

ALIREZA ROWHANIMANESH, and MOHAMMAD REZA AKBARZADEH TOTONCHI, “AUTONOMOUS DRUG-ENCAPSULATED NANOPARTICLES: TOWARDS A NOVEL NON-INVASIVE APPROACH TO PREVENT ATHEROSCLEROSIS,” IRANIAN JOURNAL OF MEDICAL PHYSICS, vol. 10, no. 3, pp. 118–132, 2013, [Online]. Available: https://sid.ir/paper/630484/en

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