GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE

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TAHERGORABI ZOYA; RASHIDI BAHMAN; KHAZAEI MAJID

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:8 Page(s): 941-945

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Title

GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE

Author(s)

TAHERGORABI ZOYA | RASHIDI BAHMAN | KHAZAEI MAJID | Issue Writer Certificate

Keywords

ADIPOCYTE

ATHEROSCLEROSIS

GHRELIN

OBESITY

Abstract

Objective(s): ATHEROSCLEROSIS is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. GHRELIN has several modulatory effects on cardiovascular system. In this study, we investigated the effect of GHRELIN on aortic intima-media thickness, size and the number of ADIPOCYTE cells in obese and control mice.Materials and Methods: This study was conducted on 24 male C57BL/6 mice. The animals were divided into four groups: control, obese (received high fat diet), control+ghrelin (injected with 100 mg/Kg subcutaneously, bid) and obese+ghrelin (n=6 each). After 10 days, animals were sacrificed and epididymal adipose tissue and thoracic aortae were removed. ADIPOCYTE cell number, size and aortic intima-media thickness were evaluated.Results: GHRELIN did not change ADIPOCYTE cell number and size and aortic intima-media thickness in obese and control mice. In this study, high fat diet significantly decreased the number of ADIPOCYTE cells while increased their size (P<0.05). GHRELIN administration had no significant effect on ADIPOCYTE cell number and size in obese and control groups (P>0.05). In addition, it could not alter aortic intima-media thickness in both groups.Conclusion: Although GHRELIN has several cardiovascular effects, it seems that it could not alter the size and number of ADIPOCYTE cells and aortic intima-media thickness in diet-induced obese mice.

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APA: Copy

TAHERGORABI, ZOYA, RASHIDI, BAHMAN, & KHAZAEI, MAJID. (2013). GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(8), 941-945. SID. https://sid.ir/paper/630553/en

Vancouver: Copy

TAHERGORABI ZOYA, RASHIDI BAHMAN, KHAZAEI MAJID. GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(8):941-945. Available from: https://sid.ir/paper/630553/en

IEEE: Copy

ZOYA TAHERGORABI, BAHMAN RASHIDI, and MAJID KHAZAEI, “GHRELIN DOES NOT ALTER AORTIC INTIMA-MEDIA THICKNESS AND ADIPOSE TISSUE CHARACTERISTICS IN CONTROL AND OBESE MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 8, pp. 941–945, 2013, [Online]. Available: https://sid.ir/paper/630553/en

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