POLYMORPHISM OF THE CYTOCHROME P-450 1A1 (A2455G) IN WOMEN WITH BREAST CANCER IN EASTERN AZERBAIJAN, IRAN

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SAADATIAN HAKIMEH; GHARESOURAN JALAL; MONTAZERI VAHID; MOHAMMADI SEYYED ABOLGASEM; MOHADDES ARDEBILI SEIIED MOJTABA

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:3 Page(s): 227-230

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Title

POLYMORPHISM OF THE CYTOCHROME P-450 1A1 (A2455G) IN WOMEN WITH BREAST CANCER IN EASTERN AZERBAIJAN, IRAN

Author(s)

Keywords

BREAST CANCER

CYP1A1

POLYMORPHISM

Abstract

Objective (s): Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. The present study evaluates the existence of CYP1A1 POLYMORPHISM in a number of BREAST CANCER samples.Materials and Methods: One hundred BREAST CANCER patients and the same number of healthy controls were analyzed for the A2455G POLYMORPHISM of cytochrome P-450 1A1 by the polymerase chain reaction-restriction fragment length POLYMORPHISM technique.Results: Frequency of heterozygote genotype (A/G) indicated significant increase in case group (17%) compared to control group (7%) (OR=2.7; 95% CI=1.07-6.89; P-value=0.03). The related result of (A/A) genotype showed significantly decreased risk of BREAST CANCER (OR=0.34; P-value=0.01). Higher frequency of heterozygotes was mainly observed among premenopausal BREAST CANCER patients.Conclusion: Our results suggest that the CYP1A1 POLYMORPHISM may be useful for predicting BREAST CANCER risk in our study population.

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APA: Copy

SAADATIAN, HAKIMEH, GHARESOURAN, JALAL, MONTAZERI, VAHID, MOHAMMADI, SEYYED ABOLGASEM, & MOHADDES ARDEBILI, SEIIED MOJTABA. (2014). POLYMORPHISM OF THE CYTOCHROME P-450 1A1 (A2455G) IN WOMEN WITH BREAST CANCER IN EASTERN AZERBAIJAN, IRAN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(3), 227-230. SID. https://sid.ir/paper/630933/en

Vancouver: Copy

SAADATIAN HAKIMEH, GHARESOURAN JALAL, MONTAZERI VAHID, MOHAMMADI SEYYED ABOLGASEM, MOHADDES ARDEBILI SEIIED MOJTABA. POLYMORPHISM OF THE CYTOCHROME P-450 1A1 (A2455G) IN WOMEN WITH BREAST CANCER IN EASTERN AZERBAIJAN, IRAN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(3):227-230. Available from: https://sid.ir/paper/630933/en

IEEE: Copy

HAKIMEH SAADATIAN, JALAL GHARESOURAN, VAHID MONTAZERI, SEYYED ABOLGASEM MOHAMMADI, and SEIIED MOJTABA MOHADDES ARDEBILI, “POLYMORPHISM OF THE CYTOCHROME P-450 1A1 (A2455G) IN WOMEN WITH BREAST CANCER IN EASTERN AZERBAIJAN, IRAN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 3, pp. 227–230, 2014, [Online]. Available: https://sid.ir/paper/630933/en

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