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Title

THE COMPARATIVE EFFECTS OF AQUEOUS EXTRACT OF WALNUT (JUGLANS REGIA) LEAF AND GLIBENCLAMIDE ON SERUM GLUCOSE LEVELS OF ALLOXAN-INDUCED DIABETIC RATS

Pages

  9-14

Abstract

 Background: The use of medicinal plants for lowering GLUCOSE level in diabetic patients is of clinical importance. The present study investigated the effect of a 30-day oral administration of aqueous extract of walnut leaf and GLIBENCLAMIDE on blood GLUCOSE level in normal and diabetic RATs.Materials and Methods: In this experimental study, 120 male RATs (Sprague-Dawley, 150- 250 g) were divided into 12 equal groups as following: normal control group, normal group receiving GLIBENCLAMIDE (4 mg/kg), three normal groups receiving the extract doses of 50, 10, and 150 mg/kg, alloxan-diabetic control group (170 mg/kg), diabetic group receiving GLIBENCLAMIDE (4 mg/kg), and five diabetic groups receiving the extract in doses of 10, 50, 150, 300, and 500 mg/day by oral administration for 30 days. GLUCOSE levels of the fasting RATs were measured at 0, 7th, 14th, 21st, and 30th days using glucometer.Results: Administration of all doses and over 10 mg/kg significantly lowered the blood GLUCOSE level in normal RAT and diabetic RATs, compared with dose and duration-dependent control groups. This effect was higher for doses of 50 and 150 mg/kg in normal RATs and for doses of 300 and 500 mg/kg in diabetic RATs, similar to GLIBENCLAMIDE (4 mg/kg).Conclusion: Walnut leaf aqueous extract, depending on dose and duration, has dose and duration dependent declining effect on GLUCOSE level in normal RATs and antihyperglycemic effect on diabetic RATs, with a few side effects. This effect at some doses is greater or equal to that of GLIBENCLAMIDE.

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    APA: Copy

    NOUREDDINI, MAHDI, & REZAEE JOSHOGANI, FATAMEH. (2013). THE COMPARATIVE EFFECTS OF AQUEOUS EXTRACT OF WALNUT (JUGLANS REGIA) LEAF AND GLIBENCLAMIDE ON SERUM GLUCOSE LEVELS OF ALLOXAN-INDUCED DIABETIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(11), 9-14. SID. https://sid.ir/paper/631096/en

    Vancouver: Copy

    NOUREDDINI MAHDI, REZAEE JOSHOGANI FATAMEH. THE COMPARATIVE EFFECTS OF AQUEOUS EXTRACT OF WALNUT (JUGLANS REGIA) LEAF AND GLIBENCLAMIDE ON SERUM GLUCOSE LEVELS OF ALLOXAN-INDUCED DIABETIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(11):9-14. Available from: https://sid.ir/paper/631096/en

    IEEE: Copy

    MAHDI NOUREDDINI, and FATAMEH REZAEE JOSHOGANI, “THE COMPARATIVE EFFECTS OF AQUEOUS EXTRACT OF WALNUT (JUGLANS REGIA) LEAF AND GLIBENCLAMIDE ON SERUM GLUCOSE LEVELS OF ALLOXAN-INDUCED DIABETIC RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 11, pp. 9–14, 2013, [Online]. Available: https://sid.ir/paper/631096/en

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