COMPARISON OF PREMEDICATION WITH ORAL DIAZEPAM AND INTRANASAL MIDAZOLAM IN CHILDREN WHO ARE CANDIDATE FOR E.N.T. SURGERIES

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HARIALCHI K.; HAJIMOHAMMADI F.; ABD ELAHZADEH M.

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2002 | Volume:22 | Issue:38 Page(s): 16-20

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Title

COMPARISON OF PREMEDICATION WITH ORAL DIAZEPAM AND INTRANASAL MIDAZOLAM IN CHILDREN WHO ARE CANDIDATE FOR E.N.T. SURGERIES

Author(s)

HARIALCHI K. | HAJIMOHAMMADI F. | ABD ELAHZADEH M. | Issue Writer Certificate

Keywords

PREOPERATIVE MEDICATION - MIDAZOLAM - DIAZEPAM SEDATIONQ3

Abstract

The aim of our study is comparison of premedication with oral Diazepam and intranasal Midazolam according to the production of sedation in children and evaluation of the efficacy of premedication of these drugs.Our study is a clinical trial study. We had collected samples of four months in E.N.T operating room. The number of patients were 80 who candidated for this clinical study. These patients were divided into two age groups (1-6 years and 6-12 years old). These patients had no co-existing (ASApsI) disease; they had no history of previous surgeries. The time limit of the surgery would not exceed one hour.Two sub-groups were formed randomly based on premedication given.Group M= 0.2mg/kg Mdz intranasal 10 minutes before induction.Group D= 0.2mg/kg Dz oral 60 minutes before induction.Patients were evaluated according to the level of sedation (awake- sleepy - sleep) and amount of cooperation during the induction (excellent - nil)With Midazolam 67/5% children were sleepy and 17/5% were sleep during induction.With Diazepam 55% of the children were sleepy and 10% were asleep during induction.There is a statistical relationship between the two drugs and their sedative effects.There is significant difference in two subgroups M and D as for as sedation is concerned (P<0.05).Amount of sedation with intranasal Midazolam was greater than oral Diazepam as a premedication according to the comparison of two age groups (1-6 years and 6-12 years old) there is no statistical relationship and significant in the amount of sedation in both drugs (P>0.05) Our statistical analysis was Chi - square (X2). We therefor conclude that intranasal Midazolam is preferred as compared to oral Diazepam accordings to its fast effect and greater amount of sedation. Premedication with intranasal Midazolam was safe and efficacious in our two age groups and there is no difference in production of sedation.

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APA: Copy

HARIALCHI, K., HAJIMOHAMMADI, F., & ABD ELAHZADEH, M.. (2002). COMPARISON OF PREMEDICATION WITH ORAL DIAZEPAM AND INTRANASAL MIDAZOLAM IN CHILDREN WHO ARE CANDIDATE FOR E.N.T. SURGERIES. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 22(38), 16-20. SID. https://sid.ir/paper/63111/en

Vancouver: Copy

HARIALCHI K., HAJIMOHAMMADI F., ABD ELAHZADEH M.. COMPARISON OF PREMEDICATION WITH ORAL DIAZEPAM AND INTRANASAL MIDAZOLAM IN CHILDREN WHO ARE CANDIDATE FOR E.N.T. SURGERIES. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2002;22(38):16-20. Available from: https://sid.ir/paper/63111/en

IEEE: Copy

K. HARIALCHI, F. HAJIMOHAMMADI, and M. ABD ELAHZADEH, “COMPARISON OF PREMEDICATION WITH ORAL DIAZEPAM AND INTRANASAL MIDAZOLAM IN CHILDREN WHO ARE CANDIDATE FOR E.N.T. SURGERIES,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 22, no. 38, pp. 16–20, 2002, [Online]. Available: https://sid.ir/paper/63111/en

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