Does Thiamine reduce the serum level of lactate after coronary artery bypass graft surgery?

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Salaheghe Shirin; Mirtajani Seyyed Bashir; Moradi Mahtab; Bahram Baygi Fateme; Farzaneghan Behrouz

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2018 | Volume:40 | Issue:3 (103) Page(s): 34-44

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Title

Does Thiamine reduce the serum level of lactate after coronary artery bypass graft surgery?

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Keywords

ThiamineQ2

Coronary artery bypass graftQ1

Systolic dysfunctionQ1

LactateQ2

Abstract

Introduction: During cardiopulmonary bypass, oxidative stress happens in the patient's cells due to blood contact with various levels of synthetic materials. It can activate inflammatory process and release factors such as IL-6, CRP, and Neutrophils which may hurt different organs. In recent years, many efforts have been made to prevent this type of damage, however, no single treatment has been proposed to reduce this risk. Antioxidant substances such as Thiamine is important in cell defense against free oxygen radicals. Regarding this issue, in this study, the effect of Thiamine on Lactate levels in patients undergoing Coronary artery bypass graft surgery has been investigated. Materials and methods: In this study, 140 patients from 25 to 65 years old with mild Systolic dysfunction (EF = 45-55%) who were candidates for elective CABG surgery in two groups: control and purpose (patients receiving Thiamine) were examined. All of these patients were anesthetized in an identical manner, and were subjected to a heart-lung pump. Serum Lactate levels were measured before, during and 6, 12, 18, and 24 hours after surgery. All data collected in a questionnaire were recorded and evaluated using spss statistical software. Results: Study groups showed no significant differences regarding demographics and underlying diseases. Serum Lactate was significantly lower in Thiamine group during the first 24 hours after surgery (except before operation and 2 hours later) (p <0. 05). Creatinine level in two groups before surgery was not significantly different, However, it was significantly lower in case group 24 hours after surgery (1. 54± 0. 14 vs. 1. 24± 0. 19; p: 0. 001). Also, dose of Inotropes in patients who received Thiamine, was significantly lower than the control group (p= 0. 001). Exudation was longer in control group (15. 4± 4. 9 vs. 13. 15± 4. 1; p=0. 003) while ICU stay was not different. Conclusion: It seems that Thiamine administration before cardiopulmonary bypass, in patient with decreased left ventricular function, can decrease serum Lactate as tissue perfusion marker and also improve kidney function.

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APA: Copy

Salaheghe, Shirin, Mirtajani, Seyyed Bashir, Moradi, Mahtab, Bahram Baygi, Fateme, & Farzaneghan, Behrouz. (2018). Does Thiamine reduce the serum level of lactate after coronary artery bypass graft surgery?. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 40(3 (103) ), 34-44. SID. https://sid.ir/paper/63112/en

Vancouver: Copy

Salaheghe Shirin, Mirtajani Seyyed Bashir, Moradi Mahtab, Bahram Baygi Fateme, Farzaneghan Behrouz. Does Thiamine reduce the serum level of lactate after coronary artery bypass graft surgery?. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2018;40(3 (103) ):34-44. Available from: https://sid.ir/paper/63112/en

IEEE: Copy

Shirin Salaheghe, Seyyed Bashir Mirtajani, Mahtab Moradi, Fateme Bahram Baygi, and Behrouz Farzaneghan, “Does Thiamine reduce the serum level of lactate after coronary artery bypass graft surgery?,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 40, no. 3 (103) , pp. 34–44, 2018, [Online]. Available: https://sid.ir/paper/63112/en

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