EFFECTS OF MULTIVITAMINS AND KNOWN TERATOGENS ON CHICK CARDIOMYOCYTES MICROMASS CULTURE ASSAY

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MEMON SAMREEN; PRATTEN MARGARET

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:9 Page(s): 996-1003

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Title

EFFECTS OF MULTIVITAMINS AND KNOWN TERATOGENS ON CHICK CARDIOMYOCYTES MICROMASS CULTURE ASSAY

Author(s)

MEMON SAMREEN | PRATTEN MARGARET | Issue Writer Certificate

Keywords

CHICK CARDIOMYOCYTE

ENVIRONMENTAL TERATOGENS

MICROMASS CULTURE

MULTIVITAMINS

Abstract

Objective(s): This study aimed to find out whether the CHICK CARDIOMYOCYTE micromass (MM) system could be employed to predict the teratogenecity of common environmental factors. Different MULTIVITAMINS and over the counter drugs were used in this study.Materials and Methods: White Leghorn 5-day-old embryo hearts were dissected and trypsinized to produce a cardiomyocyte cell suspension in Dulbecco’s Modified Eagle's Medium. The cultures were incubated at 37oC in 5% CO2 in air, and observations were made at 24, 48 and 144 hr, for the detection of cell beating. Cellular viability was assessed using the resazurin assay and cell protein content was assessed by the kenacid blue assay. It was observed that while not affecting total cell number folic acid, vitamin C, sodium fluoride and ginseng did not significantly reduced cell activity and beating. However cadmium chloride significantly reduced the beating, cell viability and cell protein content in MICROMASS CULTUREs.Results: The results demonstrate the potential of the CHICK CARDIOMYOCYTE MM culture assay to identify teratogens/embryotoxins that alter morphology and function, which may result in either teratogenic outcome or cytotoxicity.Conclusion: This could form part of a screen for developmental toxicity related to cardiac function.

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APA: Copy

MEMON, SAMREEN, & PRATTEN, MARGARET. (2013). EFFECTS OF MULTIVITAMINS AND KNOWN TERATOGENS ON CHICK CARDIOMYOCYTES MICROMASS CULTURE ASSAY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(9), 996-1003. SID. https://sid.ir/paper/631159/en

Vancouver: Copy

MEMON SAMREEN, PRATTEN MARGARET. EFFECTS OF MULTIVITAMINS AND KNOWN TERATOGENS ON CHICK CARDIOMYOCYTES MICROMASS CULTURE ASSAY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(9):996-1003. Available from: https://sid.ir/paper/631159/en

IEEE: Copy

SAMREEN MEMON, and MARGARET PRATTEN, “EFFECTS OF MULTIVITAMINS AND KNOWN TERATOGENS ON CHICK CARDIOMYOCYTES MICROMASS CULTURE ASSAY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 9, pp. 996–1003, 2013, [Online]. Available: https://sid.ir/paper/631159/en

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