EFFECT OF ORAL TIZANIDINE ON POST OPERATIVE PAIN

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NOUROUZI MEHRDAD; DOUROUDIAN M.R.; NASHIBI M.; AHMADINEZHAD MAHDI

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2009 | Volume:31 | Issue:67 Page(s): 24-32

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Title

EFFECT OF ORAL TIZANIDINE ON POST OPERATIVE PAIN

Author(s)

NOUROUZI MEHRDAD | DOUROUDIAN M.R. | NASHIBI M. | AHMADINEZHAD MAHDI | Issue Writer Certificate

Keywords

TIZANIDINEQ2

POST OPERATIVE PAINQ3

MEPERIDINEQ3

Abstract

Background: TIZANIDINE is a clonidine derivative and 2-adrenoreceptor agonist that has the same effects (sedation, anxiolysis and analgesia) but lesser side effects (hypotension and bradycardia). In these study effects of oral TIZANIDINE on POST OPERATIVE PAIN was evaluated.Materials and methods: In this clinical trial double blind study sixty patients (ASA I, II), aged 18-60yr, were randomly allocated into two groups. 90 minutes before induction of anesthesia both control and TIZANIDINE group received placebo and 4mg oral TIZANIDINE respectively. Pain severity and sedation score were assessed before and after receiving placebo or TIZANIDINE and in the first 24hr post operative period, MEPERIDINE requirements were assessed.Results: Pain severity and MEPERIDINE requirements in the TIZANIDINE group was significantly lower than that in the control group (p<0.001). Sedation score was significantly higher than that in the TIZANIDINE group (p<0.001). Conclusion: It was possible to reduce the POST OPERATIVE PAIN by oral administration of 4 mg TIZANIDINE as premedication. Therefore, we recommended premedication with TIZANIDINE for patients undergoing surgery.

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APA: Copy

NOUROUZI, MEHRDAD, DOUROUDIAN, M.R., NASHIBI, M., & AHMADINEZHAD, MAHDI. (2009). EFFECT OF ORAL TIZANIDINE ON POST OPERATIVE PAIN. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 31(67), 24-32. SID. https://sid.ir/paper/63143/en

Vancouver: Copy

NOUROUZI MEHRDAD, DOUROUDIAN M.R., NASHIBI M., AHMADINEZHAD MAHDI. EFFECT OF ORAL TIZANIDINE ON POST OPERATIVE PAIN. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2009;31(67):24-32. Available from: https://sid.ir/paper/63143/en

IEEE: Copy

MEHRDAD NOUROUZI, M.R. DOUROUDIAN, M. NASHIBI, and MAHDI AHMADINEZHAD, “EFFECT OF ORAL TIZANIDINE ON POST OPERATIVE PAIN,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 31, no. 67, pp. 24–32, 2009, [Online]. Available: https://sid.ir/paper/63143/en

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