EVALUATION OF EEFECT OF PRETREATMENT WITH EPHEDRINE IN INTENSITY OF PAIN ON INJECTION AND HEMODYNAMIC CHANGES OF PROPOFOL IN COMPARISON WITH LIDOCAINE AND PLACEBO

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MOVAFEGH ALI; SHADVAR KAMRAN; AKBARINEZHAD SEYED MANSOOR

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2007 | Volume:29 | Issue:60 Page(s): 15-21

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Title

EVALUATION OF EEFECT OF PRETREATMENT WITH EPHEDRINE IN INTENSITY OF PAIN ON INJECTION AND HEMODYNAMIC CHANGES OF PROPOFOL IN COMPARISON WITH LIDOCAINE AND PLACEBO

Author(s)

MOVAFEGH ALI | SHADVAR KAMRAN | AKBARINEZHAD SEYED MANSOOR | Issue Writer Certificate

Keywords

PROPOFOLQ3

EPHEDRINEQ3

PAIN ON INJECTIONQ3

HEMODYNAMICQ2

Abstract

Background: Today, PROPOFOL is the most commonly used drug for induction of anesthesia. With the induction dose of PROPOFOL, HEMODYNAMIC changes such as decreases in systolic and diastolic blood pressure and heart rate can occur. PAIN ON INJECTION is another side effect of this drug. Many methods have been used for reduction of this pain. The purpose of this study was to evaluate HEMODYNAMIC changes and pain reduction of two small doses of ephedeine (30, mg/kg and 70, mg/kg) after induction dose of PROPOFOL compared with lidocaine and placebo.Materials and methods: 100 patients aging 19-49 year ASA 1, 2 scheduled for electiv surgery under general anesthesia were entered in a prospective double blinded randomized clinical trial. All patients' were visited in wards the day before operation and visual analog scale (VAS) for pain was explained to them. In the operating room, pulseoximetry, ECG monitoring and non invasive blood pressure monitoring (NIBP) were established. Patients were randomly allocated into 4 groups, each group including 25 patients. Patients received 2 ml normal saline as placebo in group A, 2ml 2% lidocaine in group B, 30, mg/kg EPHEDRINE in group C and 70, mg/kg EPHEDRINE in group D. After 30 sec PROPOFOL 2.5 mg/kg was infused through the same line with an infusion rate of 1mils. A blinded anesthesiologist asked the patient to evaluate VAS every 5 sec. The maximum pain score was recorded. BP and HR were measured before and after induction and 1, 3, 5 minutes after intubation.Results: There were no demographic differences such as age and gender between the groups. Systolic, diastolic and mean arterial pressure (MAP) and HR after induction in group C and 0 were higher than group A and B respectively (p<0.05). There were no differences in systolic, diastolic and mean arterial pressure and HR 1, 3, 5 min after intubation in 4 groups. Lidocaine and two doses of EPHEDRINE reduce the PAIN ON INJECTION of PROPOFOL with the same value (p<0.05).Discussion: Compared with placebo, lidocaine and the two doses of EPHEDRINE reduce the intensity of PAIN ON INJECTION of PROPOFOL. Small doses of EPHEDRINE attenuate BP and HR reduction after induction of anesthesia with PROPOFOL.

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APA: Copy

MOVAFEGH, ALI, SHADVAR, KAMRAN, & AKBARINEZHAD, SEYED MANSOOR. (2007). EVALUATION OF EEFECT OF PRETREATMENT WITH EPHEDRINE IN INTENSITY OF PAIN ON INJECTION AND HEMODYNAMIC CHANGES OF PROPOFOL IN COMPARISON WITH LIDOCAINE AND PLACEBO. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 29(60), 15-21. SID. https://sid.ir/paper/63195/en

Vancouver: Copy

MOVAFEGH ALI, SHADVAR KAMRAN, AKBARINEZHAD SEYED MANSOOR. EVALUATION OF EEFECT OF PRETREATMENT WITH EPHEDRINE IN INTENSITY OF PAIN ON INJECTION AND HEMODYNAMIC CHANGES OF PROPOFOL IN COMPARISON WITH LIDOCAINE AND PLACEBO. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2007;29(60):15-21. Available from: https://sid.ir/paper/63195/en

IEEE: Copy

ALI MOVAFEGH, KAMRAN SHADVAR, and SEYED MANSOOR AKBARINEZHAD, “EVALUATION OF EEFECT OF PRETREATMENT WITH EPHEDRINE IN INTENSITY OF PAIN ON INJECTION AND HEMODYNAMIC CHANGES OF PROPOFOL IN COMPARISON WITH LIDOCAINE AND PLACEBO,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 29, no. 60, pp. 15–21, 2007, [Online]. Available: https://sid.ir/paper/63195/en

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