COMPARISON OF DIFFERENT DOSES OF REMIFENTANIL IN BLUNTING HOMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATIONS IN HYPERTENSIVE PATIENTS

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GHIAMAT M.M.; JAFARI A.R.; ROOHANIFAR R.

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2003 | Volume:22 | Issue:40 Page(s): 43-50

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Title

COMPARISON OF DIFFERENT DOSES OF REMIFENTANIL IN BLUNTING HOMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATIONS IN HYPERTENSIVE PATIENTS

Author(s)

GHIAMAT M.M. | JAFARI A.R. | ROOHANIFAR R. | Issue Writer Certificate

Keywords

REMIFENTANILQ3

HYPERTENSIONQ3

LARYNGOSCOPYQ3

INTUBATIONQ4

TIVAQ4

Abstract

Laryngoscope and tracheal INTUBATIONs may be accompanied by tachycardia, HYPERTENSION and myocardial ischemia in susceptible individuals. In a double blind study we have compared effect of different doses of REMIFENTANIL on homodynamic responses to tracheal INTUBATION in hypertensive patients.60 hypertensive patients, ASA class II, between 40-80 years old who were candidate for elective ophthalmic surgery were divided to three groups. All patients received normal saline or ringer’s lactate solution 5 ml/kg about 5-10 minutes before induction.Group 1, 2, 3 received REMIFENTANIL 1μg/kg, 2μg/kg, 4μg/kg respectively during induction of anesthesia in 30 seconds then an unique method of TIVA was used for all patients. Propofol 0.5mg/kg was given bolus dose and 10mg every 10 seconds until loss of verbal contact and then cistracurium 0.2mg/kg was injected IV and then the patients were ventilated for 3 minutes with O2 100% and finally intubated with proper ETT.For maintenance of anesthesia propofol 50μg/kg and REMIFENTANIL 0.05μg/kg were given.Systolic and diastolic blood pressure, MAP and heart rate were recorded before and 1, 3 minutes after induction and 1, 3, 5 minutes after INTUBATION of anesthesia.Systolic and diastolic blood pressure, MAP and heart rate were significantly decreased after induction in all groups (p<0.05) and were increased significantly after INTUBATION group 1 which was continued till third minute after INTUBATION but increasing these variables were not significant after INTUBATION in group 2 and 3. Frequency of hypertention in group 3 was significantly more than other groups (25% vs 10%, p<0.05). In third and fifth minutes after INTUBATION 10% (2 patients) in group 1 and 25% (5 patients) in group 3 had bradycardia. REMIFENTANIL 2μg/kg in hypertensive patients blunted haemodynamic responses to INTUBATION and higher doses has more frequency of hypotension and bradycardia. For decreasing these complications extensive studies in large samples with premeditation by vagolytic drugs is suggested.

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APA: Copy

GHIAMAT, M.M., JAFARI, A.R., & ROOHANIFAR, R.. (2003). COMPARISON OF DIFFERENT DOSES OF REMIFENTANIL IN BLUNTING HOMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATIONS IN HYPERTENSIVE PATIENTS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 22(40), 43-50. SID. https://sid.ir/paper/63217/en

Vancouver: Copy

GHIAMAT M.M., JAFARI A.R., ROOHANIFAR R.. COMPARISON OF DIFFERENT DOSES OF REMIFENTANIL IN BLUNTING HOMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATIONS IN HYPERTENSIVE PATIENTS. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2003;22(40):43-50. Available from: https://sid.ir/paper/63217/en

IEEE: Copy

M.M. GHIAMAT, A.R. JAFARI, and R. ROOHANIFAR, “COMPARISON OF DIFFERENT DOSES OF REMIFENTANIL IN BLUNTING HOMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATIONS IN HYPERTENSIVE PATIENTS,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 22, no. 40, pp. 43–50, 2003, [Online]. Available: https://sid.ir/paper/63217/en

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