Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

463
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

277
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

RADIOPROTECTIVE EFFECT OF MELATONIN ON RADIATION-INDUCED LUNG INJURY AND LIPID PEROXIDATION IN RATS

Pages

  111-120

Abstract

 Objective: Free radicals generated by ionizing RADIATION attack various cellular components such as lipids. The lung is a very radiosensitive organ and its damage is a doselimiting factor in radiotherapy treatments. MELATONIN (MLT), the major product of the pineal gland acts as a radioprotective agent. This study aims to investigate the radioprotective effects of MLT on malondialdehyde (MDA) levels and histopathological changes in irradiated lungs.Materials and Methods: In this experimental study, a total of 62 rats were divided into five groups. Group 1 received no MLT and RADIATION (unT), group 2 received oral MLT (oM), group 3 received oral MLT and their thoracic areas were irradiated with 18 Gy (oMR), group 4 received MLT by intraperitoneal (i.p.) injection and their thoracic areas were irradiated with 18 Gy (ipM-R), group 5 received only 18 Gy RADIATION in the thoracic area (R). Following radiotherapy, half of the animals in each group were sacrificed at 48 hours for evaluation of lipid peroxidation and early phase lung injuries. Other animals were sacrificed in the eighth week of the experiment for evaluation of the presence of late phase RADIATION induced lung injuries.Results: Pre-treatment of rats with either i.p injection (p<0.05) and oral administration of MLT (p<0.001) significantly reduced MDA levels in red blood cell (RBC) samples compared to the R group. Furthermore, i.p. injection of MLT decreased MDA levels in plasma and tissue (p<0.05). In the early phase of lung injury, both administration of MLT significantly increased lymphocyte (p<0.05) and macrophage frequency (p<0.001). MLT reduced the lung injury index in the lungs compared to the R group (p<0.05).Conclusion: The result of this study confirms the radioprotective effect of MLT on lipid peroxidation, and in both early and late phases of RADIATION induced lung injuries in an animal model.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    TAHAMTAN, RAZIYEH, SHABESTANI MONFARED, ALI, TAHAMTANI, YASSER, TAVASSOLI, ALIREZA, AKMALI, MAASOOMEH, MOSLEH SHIRAZI, MOHAMMAD AMIN, NAGHIZADEH, MOHAMMAD MEHDI, GHASEMI, DANIAL, KESHAVARZ, MOJTABA, & HADDADI, GHOLAMHASSAN. (2015). RADIOPROTECTIVE EFFECT OF MELATONIN ON RADIATION-INDUCED LUNG INJURY AND LIPID PEROXIDATION IN RATS. CELL JOURNAL (YAKHTEH), 17(1 (65)), 111-120. SID. https://sid.ir/paper/632911/en

    Vancouver: Copy

    TAHAMTAN RAZIYEH, SHABESTANI MONFARED ALI, TAHAMTANI YASSER, TAVASSOLI ALIREZA, AKMALI MAASOOMEH, MOSLEH SHIRAZI MOHAMMAD AMIN, NAGHIZADEH MOHAMMAD MEHDI, GHASEMI DANIAL, KESHAVARZ MOJTABA, HADDADI GHOLAMHASSAN. RADIOPROTECTIVE EFFECT OF MELATONIN ON RADIATION-INDUCED LUNG INJURY AND LIPID PEROXIDATION IN RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(1 (65)):111-120. Available from: https://sid.ir/paper/632911/en

    IEEE: Copy

    RAZIYEH TAHAMTAN, ALI SHABESTANI MONFARED, YASSER TAHAMTANI, ALIREZA TAVASSOLI, MAASOOMEH AKMALI, MOHAMMAD AMIN MOSLEH SHIRAZI, MOHAMMAD MEHDI NAGHIZADEH, DANIAL GHASEMI, MOJTABA KESHAVARZ, and GHOLAMHASSAN HADDADI, “RADIOPROTECTIVE EFFECT OF MELATONIN ON RADIATION-INDUCED LUNG INJURY AND LIPID PEROXIDATION IN RATS,” CELL JOURNAL (YAKHTEH), vol. 17, no. 1 (65), pp. 111–120, 2015, [Online]. Available: https://sid.ir/paper/632911/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top