EVALUATION OF THE EFFECTS OF MAGNESIUM SULFATE ON REDUCING THE NEUROENDOCRINE HORMONE, STRESS AND ACUTE PHASE RESPONSES AFTER LAPAROSCOPY

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HASANI V.A.; ESFAHANI A.M.; HOSSAINI GOHARI L.; NASERNAZHAD SH.; ENTEZARI S.R.

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2003 | Volume:24 | Issue:43 Page(s): 32-40

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Title

EVALUATION OF THE EFFECTS OF MAGNESIUM SULFATE ON REDUCING THE NEUROENDOCRINE HORMONE, STRESS AND ACUTE PHASE RESPONSES AFTER LAPAROSCOPY

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Keywords

MAGNESIUM SULFATEQ3

NEUROENDOCRINE RESPONSESQ4

LARYNGOSCOPYQ4

Abstract

Reducing NEUROENDOCRINE RESPONSES to surgical trauma during anesthesia has always attracted the attention of anesthesiologists. To achieve the goal, drugs such as beta blocker's, clonidin, opioids and local anestheties are commonly used before painful stimulation has started. MAGNESIUM SULFATE is another drug which has been used for this purpose.To evaluate the effects of MAGNESIUM SULFATE on reducing the neuroendocrine, stress and acute phase responses, in a double blind randomized clinical trial study 50 patients aged 15-45 yr. ASA I, II undergoing laparoscopic surgery under general anaesthasia were studied.Patients were divided in two groups with 25 patients in each group.One group received an infusion of Mgs04 10%, 0.25ml/kg in 20 minutes before induction of anesthesia, while control group, received an infusion of normal saline 0/25 ml/kg in 20 minutes before induction of anesthesia. During surgery the patients received these components at a rate of 0.04 ml/kg/hr via the infusion pumps. Anesthesia was induced with midazolam 0/1 mg/kg fentanyl 3mg/kg and atracurium 0.4 mg/kg as a muscle relaxant. For the maintenance of anesthesia midazolam infusion 1mcg/kg/min. Fentanyl 1 mcg/kg was administered. Then the level of neuroendocrine hormones in serum was measured by using radio-Immunoassay method.We concluded that in contrast to previous studies, no significant reduction in norepinephrine level was noted following administration of magnesium sulfnte given before LARYNGOSCOPY.

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APA: Copy

HASANI, V.A., ESFAHANI, A.M., HOSSAINI GOHARI, L., NASERNAZHAD, SH., & ENTEZARI, S.R.. (2003). EVALUATION OF THE EFFECTS OF MAGNESIUM SULFATE ON REDUCING THE NEUROENDOCRINE HORMONE, STRESS AND ACUTE PHASE RESPONSES AFTER LAPAROSCOPY. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 24(43), 32-40. SID. https://sid.ir/paper/63380/en

Vancouver: Copy

HASANI V.A., ESFAHANI A.M., HOSSAINI GOHARI L., NASERNAZHAD SH., ENTEZARI S.R.. EVALUATION OF THE EFFECTS OF MAGNESIUM SULFATE ON REDUCING THE NEUROENDOCRINE HORMONE, STRESS AND ACUTE PHASE RESPONSES AFTER LAPAROSCOPY. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2003;24(43):32-40. Available from: https://sid.ir/paper/63380/en

IEEE: Copy

V.A. HASANI, A.M. ESFAHANI, L. HOSSAINI GOHARI, SH. NASERNAZHAD, and S.R. ENTEZARI, “EVALUATION OF THE EFFECTS OF MAGNESIUM SULFATE ON REDUCING THE NEUROENDOCRINE HORMONE, STRESS AND ACUTE PHASE RESPONSES AFTER LAPAROSCOPY,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 24, no. 43, pp. 32–40, 2003, [Online]. Available: https://sid.ir/paper/63380/en

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