CARDIOVASCULAR EFFECTS OF REMIFENTANIL AND PROPOFOL IN COMPARISON TO PLACEBO IN ELECTRO CONVULSIVE THERAPY

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BORJIAN BOROUJENI SH.; ENAYATI H.; MOKARAM DORI M.; MASOUMI S.GH.R.

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Paper Information

Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2005 | Volume:27 | Issue:49 Page(s): 28-34

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Title

CARDIOVASCULAR EFFECTS OF REMIFENTANIL AND PROPOFOL IN COMPARISON TO PLACEBO IN ELECTRO CONVULSIVE THERAPY

Author(s)

BORJIAN BOROUJENI SH. | ENAYATI H. | MOKARAM DORI M. | MASOUMI S.GH.R. | Issue Writer Certificate

Keywords

ELECTROCONVULSIVE THERAPYQ3

PROPOFOLQ4

REMIFENTINGQ3

Abstract

Background and Objective: Electro convulsive therapy is an effective treatment in many psychiatric disorders such as major depression or schizophrenia. Hypertension, tachycardia myocardial ischemia or infarction and cerebrovasular accident are complications of ECT. We designed this clinical trial, prospective, double blinded; placebo controlled and crosses over study to compare cardiovascular effects of different remifentanil doses in standardized ECT. Materials and Method: 22 depressed patients were studied. Each patient received four times ECT which was given every other day. Before induction of anesthesia the patients were premedicated with 0.5 of atropine and one of the three doses of remifentamil (25, 50, 100 µg) or placebo. Anesthesia was induced with PROPOFOL 0.75 mg/kg and succinyl choline 1.2 mg/kg. Then electrical stimulation above the threshold was applied. We recorded heart rate (HR) systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP). Before any drug administration, before electrical stimulation, at 1- minute intervals, and 12, 15, 20 , 25 minutes after ECT. The time of electroencephalographic convulsion, motor convulsion, recovery time, obeys of commands and spontaneous breathing was the same in all patients. Results: The peak HR after ECT was significantly lower in 100 μg group compared with the placebo group. We concluded that 100 μg remifentanil can modify hyperdynamic responses in ECT.

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APA: Copy

BORJIAN BOROUJENI, SH., ENAYATI, H., MOKARAM DORI, M., & MASOUMI, S.GH.R.. (2005). CARDIOVASCULAR EFFECTS OF REMIFENTANIL AND PROPOFOL IN COMPARISON TO PLACEBO IN ELECTRO CONVULSIVE THERAPY. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 27(49), 28-34. SID. https://sid.ir/paper/63424/en

Vancouver: Copy

BORJIAN BOROUJENI SH., ENAYATI H., MOKARAM DORI M., MASOUMI S.GH.R.. CARDIOVASCULAR EFFECTS OF REMIFENTANIL AND PROPOFOL IN COMPARISON TO PLACEBO IN ELECTRO CONVULSIVE THERAPY. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2005;27(49):28-34. Available from: https://sid.ir/paper/63424/en

IEEE: Copy

SH. BORJIAN BOROUJENI, H. ENAYATI, M. MOKARAM DORI, and S.GH.R. MASOUMI, “CARDIOVASCULAR EFFECTS OF REMIFENTANIL AND PROPOFOL IN COMPARISON TO PLACEBO IN ELECTRO CONVULSIVE THERAPY,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 27, no. 49, pp. 28–34, 2005, [Online]. Available: https://sid.ir/paper/63424/en

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