EVALUATION OF SERUM LEVEL OF ALPHA-1 ANTITRYPSIN BY CAPILLARY ZONE ELECTROPHORESIS IN PATIENTS WITH MULTIPLE MYELOMA STAGE I

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Mahabadi sonya; KHADEM ANSARI MOHAMMAD HASSAN; KHERADMAND FATEMEH; Samadpour Maqhsoudlou Mohammad

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Journal: Studies in Medical Sciences Year:2016 | Volume:27 | Issue:4 Page(s): 345-351

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Title

EVALUATION OF SERUM LEVEL OF ALPHA-1 ANTITRYPSIN BY CAPILLARY ZONE ELECTROPHORESIS IN PATIENTS WITH MULTIPLE MYELOMA STAGE I

Author(s)

Mahabadi sonya | KHADEM ANSARI MOHAMMAD HASSAN | KHERADMAND FATEMEH | Samadpour Maqhsoudlou Mohammad | Issue Writer Certificate

Keywords

MULTIPLE MYELOMAQ2

ACUTE PHASE PROTEINSQ1

ALPHA-1 ANTITRYPSINQ1

Abstract

Background & Aims: ACUTE PHASE PROTEINS are synthesized mainly by the liver and macrophages in an inflammatory conditions as a result of some trauma and malignancies. Increased levels of these proteins have been reported in many cancer tumors and MULTIPLE MYELOMA as an important indicator of prognosis of malignancies. Because of importance of this issue, we investigate the serum level of alpha- 1antitrypsin in MULTIPLE MYELOMA stage I.Materials & Methods: The serum level of alpha-1antitrypsin was measured 30 in patients with MULTIPLE MYELOMA stage I and 30 persons as a control group. Patients aged 69 years. Measuring ALPHA-1 ANTITRYPSIN by using Capillary zone electrophoresis and high resolution (HR) and total protein by biuret method. The data were analyzed by SPSS program.Results: The values obtained from results of the test and statistical calculations in two groups of patients and control showed that serum ALPHA-1 ANTITRYPSIN level in MULTIPLE MYELOMA stage I (0.37±0.21) compared to the control group (0.82 ± 0.16) was decreased. The reduction was significant. (P=0.0001) Conclusion: The results of this study indicate the reduction of serum ALPHA-1 ANTITRYPSIN in stage I patients compared to control group, which is inconsistent with previous studies in this field. These proteins may considered as specific prognostic and diagnostic factors in MULTIPLE MYELOMA stage I.However, further studies are needed to asses’ accurate results.

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APA: Copy

Mahabadi, sonya, KHADEM ANSARI, MOHAMMAD HASSAN, KHERADMAND, FATEMEH, & Samadpour Maqhsoudlou, Mohammad. (2016). EVALUATION OF SERUM LEVEL OF ALPHA-1 ANTITRYPSIN BY CAPILLARY ZONE ELECTROPHORESIS IN PATIENTS WITH MULTIPLE MYELOMA STAGE I. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(4), 345-351. SID. https://sid.ir/paper/63581/en

Vancouver: Copy

Mahabadi sonya, KHADEM ANSARI MOHAMMAD HASSAN, KHERADMAND FATEMEH, Samadpour Maqhsoudlou Mohammad. EVALUATION OF SERUM LEVEL OF ALPHA-1 ANTITRYPSIN BY CAPILLARY ZONE ELECTROPHORESIS IN PATIENTS WITH MULTIPLE MYELOMA STAGE I. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;27(4):345-351. Available from: https://sid.ir/paper/63581/en

IEEE: Copy

sonya Mahabadi, MOHAMMAD HASSAN KHADEM ANSARI, FATEMEH KHERADMAND, and Mohammad Samadpour Maqhsoudlou, “EVALUATION OF SERUM LEVEL OF ALPHA-1 ANTITRYPSIN BY CAPILLARY ZONE ELECTROPHORESIS IN PATIENTS WITH MULTIPLE MYELOMA STAGE I,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 4, pp. 345–351, 2016, [Online]. Available: https://sid.ir/paper/63581/en

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