مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ROLE OF MORPHINE PRECONDITIONING AND NITRIC OXIDE FOLLOWING BRAIN ISCHEMIA REPERFUSION INJURY IN MICE

Pages

  14-21

Abstract

 Objective(s): MORPHINE dependence (MD) potently protects heart against ischemia reperfusion (IR) injury through specific signaling mechanisms, which are different from the pathways involved in acute MORPHINE treatment or classical preconditioning. Since opioid receptor density changes post cerebral ischemia strongly correlated with brain histological damage, in the present study, we tried to elucidate the possible role of opioid receptors in IR injury among MORPHINE-dependent mice.Materials and Methods: Accordingly, incremental doses (10 mg/kg/day to 30 mg/kg/day) of MORPHINE sulphate were subcutaneously administered for 5 days before GLOBAL BRAIN ISCHEMIA induction through bilateral common carotid artery occlusion. Animals were received naloxone (5 mg/kg) or L-NAME (20 mg/kg) 30 min after the last MORPHINE dose. Twenty four hr after the ischemia induction, Retention trial of passive avoidance test and western blot analysis were done. histological analysis (TUNEL and NISSL staining) performed 72 hr after ischemia.Results: MD improved post ischemia MEMORY performance (P<0.01) and neuronal survival (P<0.001) and decreased APOPTOSIS (P<0.05) in region I of HIPPOCAMPUS (CA1 region) in mouse. Treatment with naloxone or L-NAME abolished all MD aforementioned effects.Conclusion: Results of the present study suggested that opioid receptors activation in the early hr post ischemia is crucial for MD-induced HIPPOCAMPUS tolerance against IR injury. Opioid receptor-dependent balance of NO production was another key factor in MD-induced protection. Further studies are required to determine the effect of MD on opioid receptor changes after ischemia and its correlation with MD-induced protection.

Cites

References

Cite

APA: Copy

ARABIAN, MAEDEH, ABOUTALEB, NAHID, SOLEIMANI, MANSOUREH, ZAREH MEHRJERDI, FATEMEH, AJAMI, MARJAN, & PAZOKI TOROUDI, HAMIDREZA. (2015). ROLE OF MORPHINE PRECONDITIONING AND NITRIC OXIDE FOLLOWING BRAIN ISCHEMIA REPERFUSION INJURY IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(1), 14-21. SID. https://sid.ir/paper/635866/en

Vancouver: Copy

ARABIAN MAEDEH, ABOUTALEB NAHID, SOLEIMANI MANSOUREH, ZAREH MEHRJERDI FATEMEH, AJAMI MARJAN, PAZOKI TOROUDI HAMIDREZA. ROLE OF MORPHINE PRECONDITIONING AND NITRIC OXIDE FOLLOWING BRAIN ISCHEMIA REPERFUSION INJURY IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(1):14-21. Available from: https://sid.ir/paper/635866/en

IEEE: Copy

MAEDEH ARABIAN, NAHID ABOUTALEB, MANSOUREH SOLEIMANI, FATEMEH ZAREH MEHRJERDI, MARJAN AJAMI, and HAMIDREZA PAZOKI TOROUDI, “ROLE OF MORPHINE PRECONDITIONING AND NITRIC OXIDE FOLLOWING BRAIN ISCHEMIA REPERFUSION INJURY IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 1, pp. 14–21, 2015, [Online]. Available: https://sid.ir/paper/635866/en

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