IMMUNIZATION OF MICE WITH SONICATED ANTIGEN AGAINST HELICOBACTER FELLS AND COMPARING THE EMERGED IMMUNE RESPONSE WITH A NON IMMUNE H. FELLS INFECTED MICE

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MORSHEDI A.; MOHAMMADI M.; AHMADI ASHTIANI H.R.

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Journal: Studies in Medical Sciences Year:2006 | Volume:16 | Issue:4 Page(s): 235-240

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Title

IMMUNIZATION OF MICE WITH SONICATED ANTIGEN AGAINST HELICOBACTER FELLS AND COMPARING THE EMERGED IMMUNE RESPONSE WITH A NON IMMUNE H. FELLS INFECTED MICE

Author(s)

MORSHEDI A. | MOHAMMADI M. | AHMADI ASHTIANI H.R. | Issue Writer Certificate

Keywords

HELICOBACTER FELISQ4

GASTRITISQ4

IMMUNIZATIONQ3

MICEQ3

Abstract

Background & Aims: The role of IMMUNIZATION of MICE with sonicated antigen in protection of Helicobacter induced GASTRITIS and invitro survey of lymphocyte response in immunized/ challenged MICE in compare with infected MICE was studied. Materials & Methods: Two groups of MICE were immunized with 3 mg of sonicated antigen and along with the 2 groups of naive (non-immunized) MICE were challenged by alive H.felis. The lymphocyte proliferation index, were determined by dividing the counts obtained from Ag-stimulated cells by counting from unstimulated cell/well. The assay of IFN- γ and anti-H.felis antibodies were done by sandwich ELISA. Results: Eight weeks after challenge, the lymphocyte stimulation index in infected and Immunized/challenge MICE were respectively 45&25.lFN- γ production due to Immune/challenge and infected MICE were respectively 300 and 170 Picogram/ml. The antibodies titer of Immune/challenge and infected MICE obtained 1:8000 and 1:500 respectively. Discussion: The data showed that cellular response of immunized MICE were significantly higher (p<0.05) than infected MICE, early after challenge. Whereas, declined within 8 weeks in Immunized MICE in comparison with infected MICE. On the other hand, the higher production of IFN- γ and anti-H. felis antibody by immunized MICE, compared with infected MICE, suggest that specific response, mediated by Th1 and then Th2 (via antibody production) play a role against Helicobacter-induced GASTRITIS.

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APA: Copy

MORSHEDI, A., MOHAMMADI, M., & AHMADI ASHTIANI, H.R.. (2006). IMMUNIZATION OF MICE WITH SONICATED ANTIGEN AGAINST HELICOBACTER FELLS AND COMPARING THE EMERGED IMMUNE RESPONSE WITH A NON IMMUNE H. FELLS INFECTED MICE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 16(4), 235-240. SID. https://sid.ir/paper/63633/en

Vancouver: Copy

MORSHEDI A., MOHAMMADI M., AHMADI ASHTIANI H.R.. IMMUNIZATION OF MICE WITH SONICATED ANTIGEN AGAINST HELICOBACTER FELLS AND COMPARING THE EMERGED IMMUNE RESPONSE WITH A NON IMMUNE H. FELLS INFECTED MICE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;16(4):235-240. Available from: https://sid.ir/paper/63633/en

IEEE: Copy

A. MORSHEDI, M. MOHAMMADI, and H.R. AHMADI ASHTIANI, “IMMUNIZATION OF MICE WITH SONICATED ANTIGEN AGAINST HELICOBACTER FELLS AND COMPARING THE EMERGED IMMUNE RESPONSE WITH A NON IMMUNE H. FELLS INFECTED MICE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 16, no. 4, pp. 235–240, 2006, [Online]. Available: https://sid.ir/paper/63633/en

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