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Information Journal Paper

Title

TAIL FLICK MODIFICATION OF OREXIN-A INDUCED CHANGES OF ELECTROPHYSIOLOGICAL PARAMETERS IN THE ROSTRAL VENTROMEDIAL MEDULLA

Pages

  131-140

Keywords

Abstract

 Objective: It is well known that intracerebroventricular (ICV) and supraspinal injections of OREXIN-A elicit analgesia, but the mechanism(s) of action remains unidentified. This study aims to characterize the effect of OREXIN-A on rostral ventromedial medulla (RVM) neurons which are involved in the descending nociception modulating pathway.Materials and Methods: In this experimental study, we injected OREXIN-A or vehicle directly into rats' ICV while the TAIL FLICK (TF) latencies were measured and the on- and off-cell firing activities were monitored for more than 60 minutes.Results: In response to noxious stimuli on the tail, we observed increased firing rate of on-cells and a decreased association with the firing rate of off-cells and in neutral cells the firing rate was unchanged just prior to TAIL FLICKing. ICV injection of OREXIN-A decreased the spontaneous firing rate of on-cells (the type of RVM neurons believed to have facilitatory action on nociception). Furthermore, OREXIN-A increased firing rate of off-cells (the type of RVM neurons believed to have an inhibitory action on nociception). OREXIN-A reduced the TF-related responses of on-cells and TF-related pause duration of off-cells.Conclusion: These results have shown that the analgesic effect produced by OREXIN-A may be induced by brainstem neurons. It is suggested that the orexinergic system from the hypothalamus to the RVM may have a potential role in modulation of nociceptive transmission.

Cites

References

Cite

APA: Copy

AZHDARI ZARMEHRI, HASSAN, SEMNANIAN, SAEED, FATHOLLAHI, YAGHOUB, & GHADERI PAKDEL, FIROUZ. (2014). TAIL FLICK MODIFICATION OF OREXIN-A INDUCED CHANGES OF ELECTROPHYSIOLOGICAL PARAMETERS IN THE ROSTRAL VENTROMEDIAL MEDULLA. CELL JOURNAL (YAKHTEH), 16(2 (62)), 131-140. SID. https://sid.ir/paper/637854/en

Vancouver: Copy

AZHDARI ZARMEHRI HASSAN, SEMNANIAN SAEED, FATHOLLAHI YAGHOUB, GHADERI PAKDEL FIROUZ. TAIL FLICK MODIFICATION OF OREXIN-A INDUCED CHANGES OF ELECTROPHYSIOLOGICAL PARAMETERS IN THE ROSTRAL VENTROMEDIAL MEDULLA. CELL JOURNAL (YAKHTEH)[Internet]. 2014;16(2 (62)):131-140. Available from: https://sid.ir/paper/637854/en

IEEE: Copy

HASSAN AZHDARI ZARMEHRI, SAEED SEMNANIAN, YAGHOUB FATHOLLAHI, and FIROUZ GHADERI PAKDEL, “TAIL FLICK MODIFICATION OF OREXIN-A INDUCED CHANGES OF ELECTROPHYSIOLOGICAL PARAMETERS IN THE ROSTRAL VENTROMEDIAL MEDULLA,” CELL JOURNAL (YAKHTEH), vol. 16, no. 2 (62), pp. 131–140, 2014, [Online]. Available: https://sid.ir/paper/637854/en

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