A SURVEY OF AMYGDALA CENTRALIS CARDIOVASCULAR RESPONSE TO ANGIOTENSIN I MICROINJECTION IN RENOVASCULAR HYPERTENSIVE RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SABOURI E.; HESHMATIAN B.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2009 | Volume:19 | Issue:4 Page(s): 318-324

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

973

Download:

Cites:

Information Journal Paper

Title

A SURVEY OF AMYGDALA CENTRALIS CARDIOVASCULAR RESPONSE TO ANGIOTENSIN I MICROINJECTION IN RENOVASCULAR HYPERTENSIVE RAT

Author(s)

SABOURI E. | HESHMATIAN B. | Issue Writer Certificate

Keywords

RENIN-ANGIOTENSIN SYSTEMQ3

AMYGDALA CENTRALISQ3

TWO KIDNEYSQ3

ONE CLIP GOLDBLATT HYPERTENSIONQ3

ANGIOTENSIN IQ3

Abstract

Background & Aims: Previous studies have revealed that induction of TWO KIDNEYS, one clip Goldblatt hypertension induction in rats eliminates hypertensive response after inactivating of the central nucleus of the amygdala. The present study investigated the possibility of alteration in local rennin angiotensin system activity in central nucleus of the amygdala after hypertension induction and evaluation of cardiovascular response to ANGIOTENSIN I microinjection into central nucleus of the amygdala in wistar rats. Materials & Methods: 130 Wistar rats were studied in this investigation. Clamps were placed on the left renal arteries to induce TWO KIDNEYS, one clip Goldblatt hypertension. A similar surgery procedure without clipping was done in sham group. The rats were studied eight weeks after surgery. The mean arterial blood pressure and heart rate were measured directly with indwelling arterial cannula under urethane anesthesia. Rats received bilateral cannulation of the central nucleus of the amygdala for ANGIOTENSIN I microinjection. After bilateral microinjection of consecutive doses of ANGIOTENSIN I (0.5mL- 10mM, 10 nM and 10 pM), saline and pretreatment of losartan (10mM), saralasin (1nM) or captopril (10mM) before ANGIOTENSIN I injection into central nucleus of the amygdala, mean arterial blood pressure and heart rate were measured and compared between groups. Results: Bilateral microinjection of consecutive doses of ANGIOTENSIN I into central nucleus of the amygdala significantly increased mean arterial blood pressure and heart rate in hypertensive group in comparison to normotensive one (P<0.001). After pretreatment of saralasin and losartan the effects of 100M ANGIOTENSIN I microinjection into central nucleus of the amygdala of all groups were inhibited. Captopril inhibits effects of ANGIOTENSIN I in normotensive animals but does not in hypertensive ones. Conclusion: These results are functionally demonstration of cardiovascular effects of ANGIOTENSIN I microinjection into central nucleus of the amygdala and those effects have increased after 2K1 C hypertension induction. This process may contribute in Goldblatt hypertension pathogenesis. Increased ANGIOTENSIN II receptors or accelerated proteolytic process of ANGIOTENSIN I to ANGIOTENSIN II may alter ANGIOTENSIN I microinjection into central nucleus of the amygdala outcome.

Cites

No record.

References

No record.

Cite

APA: Copy

SABOURI, E., HESHMATIAN, B.,. (2009). A SURVEY OF AMYGDALA CENTRALIS CARDIOVASCULAR RESPONSE TO ANGIOTENSIN I MICROINJECTION IN RENOVASCULAR HYPERTENSIVE RAT. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 19(4), 318-324. SID. https://sid.ir/paper/63854/en

Vancouver: Copy

SABOURI E., HESHMATIAN B.. A SURVEY OF AMYGDALA CENTRALIS CARDIOVASCULAR RESPONSE TO ANGIOTENSIN I MICROINJECTION IN RENOVASCULAR HYPERTENSIVE RAT. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2009;19(4):318-324. Available from: https://sid.ir/paper/63854/en

IEEE: Copy

E. SABOURI, B. HESHMATIAN, an, “A SURVEY OF AMYGDALA CENTRALIS CARDIOVASCULAR RESPONSE TO ANGIOTENSIN I MICROINJECTION IN RENOVASCULAR HYPERTENSIVE RAT,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 19, no. 4, pp. 318–324, 2009, [Online]. Available: https://sid.ir/paper/63854/en

Related Journal Papers