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Information Journal Paper

Title

EFFECTS OF A HYDROALCOHOLIC EXTRACT OF WALNUT MALE FLOWERS ON DIABETIC RATS

Pages

  55-58

Abstract

 Background: DIABETES is a metabolic disorder resulting from defects in insulin secretion and function. Walnut is used in traditional medicine to treat DIABETES. In this study we evaluated the anti-diabetic effects of the HYDROALCOHOLIC EXTRACT of WALNUT MALE FLOWERS in streptozocin diabetic RATS and its probable side effects on the liver.Materials and Methods: Eighty adult male Wistar RATS were randomly selected and divided into 4 subgroups including a control (N=8) with no intervention, witness group receiving normal saline and another 3 groups of RATS each receiving either 2, 4, or 6 g/kg of the extract per day for 15 days. Diabetic groups of RATS each treated with the above doses of the extract for the aforementioned period of time, and a group of 8 diabetic RATS without any further treatment. Eight RATS were also used to determine the LD50 of streptozotocin. DIABETES was induced in RATS by injection of 60 mg/kg of streptozotocin. At the end of the experimental period, blood was taken from the experimental and control groups and the serum levels of insulin, glucose and liver enzymes (ALT, AST, ALP) were measured.Results: Results showed that the hydro-alcoholic extract of WALNUT MALE FLOWERS increased the levels of insulin, decreased blood glucose, AST and ALP enzymes in the treated diabetic groups compared to the non-treated group (p<0.05). The anti-diabetic effects of the extract were not dose dependent.Conclusion: The effectiveness of the hydro-alcoholic extract of WALNUT MALE FLOWERS in diabetic RATS through prevention of liver damage and reduction of blood glucose.

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    APA: Copy

    HOSSEINI, S. EBRAHIM, KARIMZADEH, KAZEM, & VESSAL, MAHMOOD. (2013). EFFECTS OF A HYDROALCOHOLIC EXTRACT OF WALNUT MALE FLOWERS ON DIABETIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(11), 55-58. SID. https://sid.ir/paper/639942/en

    Vancouver: Copy

    HOSSEINI S. EBRAHIM, KARIMZADEH KAZEM, VESSAL MAHMOOD. EFFECTS OF A HYDROALCOHOLIC EXTRACT OF WALNUT MALE FLOWERS ON DIABETIC RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(11):55-58. Available from: https://sid.ir/paper/639942/en

    IEEE: Copy

    S. EBRAHIM HOSSEINI, KAZEM KARIMZADEH, and MAHMOOD VESSAL, “EFFECTS OF A HYDROALCOHOLIC EXTRACT OF WALNUT MALE FLOWERS ON DIABETIC RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 11, pp. 55–58, 2013, [Online]. Available: https://sid.ir/paper/639942/en

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