SCIATIC NERVE REGENERATION IN THE PIEZOELECTRIC TUBE: THE INFLUENCE OF NGF AND IGF-I

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FARJAH G.; JOGHATAEI M.T.

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Journal: Studies in Medical Sciences Year:2006 | Volume:17 | Issue:3 Page(s): 209-218

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Title

SCIATIC NERVE REGENERATION IN THE PIEZOELECTRIC TUBE: THE INFLUENCE OF NGF AND IGF-I

Author(s)

FARJAH G. | JOGHATAEI M.T. | Issue Writer Certificate

Keywords

NERVE REGENERATIONQ3

SCIATIC NERVEQ3

NGFQ3

IGF-IQ3

PVDFQ3

Abstract

Background and Aims: The limited availabillity of donor sites for nerve grafts stimulates research toward finding suitable alternatives for autograft.Materials and Methods: This research is an experimental study that 48 male rats (200-250 gr) were used. After axotomy, 1cm segment of the SCIATIC NERVE in rats was removed and the gap was then bridged using one of four following methods (Polyvinylidene fluride or PVDF + NGF + IGF-1, Autograft, Sham, and Control). All animals were evaluated 7, 21, 35, 46, 60 and 90 days after operation by sensory test, and Sciatic Functional Index (SFI) and at 90 days by electrophysiologic testing. After 28 and 96 days of implantation SCIATIC NERVE was studied by light and electron microscope.Results: 90 days after operation, there was no difference in sensory testing between groups. After 56 days, the mean SFI autograft group was superior in NGF + IGF-I + PVDF group (p<0.01). Mean motor nerve conduction velocity in different experimental groups was not significant (p=0.05). After 28 days of implantation, the regenerated tissue cables into PVDF tube were round shaped and the mean number of myelinated axons in different experimental groups was not significant (p=0.06) After 96 days of implantation, the mean number of myelinated axons in NGF + IGF-I + PVDF group was lower than the autograft group (p<0.01).Discussion: In this study positive effects of NGF + IGF-I on regeneration of nerves through a PVDF channel shows that it may be useful in treating peripheral nerve injuries.

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APA: Copy

FARJAH, G., & JOGHATAEI, M.T.. (2006). SCIATIC NERVE REGENERATION IN THE PIEZOELECTRIC TUBE: THE INFLUENCE OF NGF AND IGF-I. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(3), 209-218. SID. https://sid.ir/paper/64058/en

Vancouver: Copy

FARJAH G., JOGHATAEI M.T.. SCIATIC NERVE REGENERATION IN THE PIEZOELECTRIC TUBE: THE INFLUENCE OF NGF AND IGF-I. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;17(3):209-218. Available from: https://sid.ir/paper/64058/en

IEEE: Copy

G. FARJAH, and M.T. JOGHATAEI, “SCIATIC NERVE REGENERATION IN THE PIEZOELECTRIC TUBE: THE INFLUENCE OF NGF AND IGF-I,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 3, pp. 209–218, 2006, [Online]. Available: https://sid.ir/paper/64058/en

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