A SURVEY OF HLA-CLASS I IN PATIENTS WITH PEMPHIGUS ADMITTED TO THE DEPARTMENT OF DERMATOLOGY IN SINA HOSPITAL, TABRIZ (AZAR 81-ABAN 82)

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BABAIE NEJAD SH.; KHODAEIANI E.; MAJIDI J.; HASHEMPOUR A.

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Journal: Studies in Medical Sciences Year:2006 | Volume:17 | Issue:3 Page(s): 162-168

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Title

A SURVEY OF HLA-CLASS I IN PATIENTS WITH PEMPHIGUS ADMITTED TO THE DEPARTMENT OF DERMATOLOGY IN SINA HOSPITAL, TABRIZ (AZAR 81-ABAN 82)

Author(s)

BABAIE NEJAD SH. | KHODAEIANI E. | MAJIDI J. | HASHEMPOUR A. | Issue Writer Certificate

Keywords

HUMAN LEUKOCYTE ANTIGENQ3

PEMPHIGUSQ4

HLAQ3

Abstract

Background and Aims: PEMPHIGUS disease is defined as a chronic autoimmune bullous skin disease that is characterized as histologic regarding intraepidermal bullae due to acantholysis. Direct causes of this disease are unknown. However, it may be related to inheritance and several other factors that play roles in its acceleration. The aim of this study is surveying HUMAN LEUKOCYTE ANTIGENs- type in patients with PEMPHIGUS, who referred to Tabriz Sina Hospital dermatology ward and clinic.Methods &Materials: In this cross - sectional study, venous blood samples of 51 patients with PEMPHIGUS who referred to Tabriz Sina Hospital dermatology ward and clinic, Azar 81- Aban 82, were evaluated to determine HUMAN LEUKOCYTE ANTIGENs with microcytotoxicity technique and were compared with the results of HLA- type in control groups.Results: In this study the most common leukocyte antigen was BW6 (49%) followed by BW4 (39%), A3 (35%) and B5 (31%). In patients with positive familial history of disease, B5 leukocyte antigen was positive in 75%.There was a significant relationship between gender and B5, CW7 leukocyte antigens (P= 0.016).The prevalence of A26 among patients with recurrent disease was 20% but HLA B35 was positive in the control groups(26%) more than the patients(6%).In this study the prevalenceofBW6 - BW4 - A3 - B5 leukocyte antigens was high that some of leukocyte antigens were common with previous studies but some of leukocyte antigens were specialized to our region.Discussion: Due to attention to specialization of some leukocyte antigens (such as BW4, BW6) to region of this study, we can use this type of antigens for screening patients with PEMPHIGUS. In this study there was a significant relationship between B5 leukocyte antigen and familial history but the prevalence of B35 was high in the control groups.

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APA: Copy

BABAIE NEJAD, SH., KHODAEIANI, E., MAJIDI, J., & HASHEMPOUR, A.. (2006). A SURVEY OF HLA-CLASS I IN PATIENTS WITH PEMPHIGUS ADMITTED TO THE DEPARTMENT OF DERMATOLOGY IN SINA HOSPITAL, TABRIZ (AZAR 81-ABAN 82). STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(3), 162-168. SID. https://sid.ir/paper/64063/en

Vancouver: Copy

BABAIE NEJAD SH., KHODAEIANI E., MAJIDI J., HASHEMPOUR A.. A SURVEY OF HLA-CLASS I IN PATIENTS WITH PEMPHIGUS ADMITTED TO THE DEPARTMENT OF DERMATOLOGY IN SINA HOSPITAL, TABRIZ (AZAR 81-ABAN 82). STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;17(3):162-168. Available from: https://sid.ir/paper/64063/en

IEEE: Copy

SH. BABAIE NEJAD, E. KHODAEIANI, J. MAJIDI, and A. HASHEMPOUR, “A SURVEY OF HLA-CLASS I IN PATIENTS WITH PEMPHIGUS ADMITTED TO THE DEPARTMENT OF DERMATOLOGY IN SINA HOSPITAL, TABRIZ (AZAR 81-ABAN 82),” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 3, pp. 162–168, 2006, [Online]. Available: https://sid.ir/paper/64063/en

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