OXIDATIVE STRESS AND HYPERTENSION: POSSIBILITY OF HYPERTENSION THERAPY WITH ANTIOXIDANTS

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BARADARAN AZAR; NASRI HAMID; RAFIEIAN KOPAEI MAHMOUD

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Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:19 | Issue:4 Page(s): 358-367

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Title

OXIDATIVE STRESS AND HYPERTENSION: POSSIBILITY OF HYPERTENSION THERAPY WITH ANTIOXIDANTS

Author(s)

BARADARAN AZAR | NASRI HAMID | RAFIEIAN KOPAEI MAHMOUD | Issue Writer Certificate

Keywords

ANTIOXIDANT

HYPERTENSION

OXIDATIVE STRESS

Abstract

Hypertension is a major risk factor for myocardial infarction, heart failure, stroke, peripheral arterial disease, and aortic aneurysm, and is a cause of chronic kidney disease. HYPERTENSION is often associated with metabolic abnormalities such as diabetes and dyslipidemia, and the rate of these diseases is increasing nowadays. Recently it has been hypothesized that OXIDATIVE STRESS is a key player in the pathogenesis of HYPERTENSION. A reduction in superoxide dismutase and glutathione peroxidase activity has been observed in newly diagnosed and untreated hypertensive subjects, which are inversely correlated with blood pressure. Hydrogen peroxide production is also higher in hypertensive subjects. Furthermore, hypertensive patients have higher lipid hydroperoxide production. OXIDATIVE STRESS is also markedly increased in hypertensive patients with renovascular disease. If OXIDATIVE STRESS is indeed a cause of HYPERTENSION, then, ANTIOXIDANTs should have beneficial effects on HYPERTENSION control and reduction of oxidative damage should result in a reduction in blood pressure. Although dietary ANTIOXIDANTs may have beneficial effects on HYPERTENSION and cardiovascular risk factors, however, ANTIOXIDANT supplementation has not been shown consistently to be effective and improvement is not usually seen in blood pressure after treatment with single or combination ANTIOXIDANT therapy in subjects thought to be at high risk of cardiovascular disease. This matter is the main focus of this paper. A list of medicinal plants that have been reported to be effective in HYPERTENSION is also presented.

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APA: Copy

BARADARAN, AZAR, NASRI, HAMID, & RAFIEIAN KOPAEI, MAHMOUD. (2014). OXIDATIVE STRESS AND HYPERTENSION: POSSIBILITY OF HYPERTENSION THERAPY WITH ANTIOXIDANTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(4), 358-367. SID. https://sid.ir/paper/640690/en

Vancouver: Copy

BARADARAN AZAR, NASRI HAMID, RAFIEIAN KOPAEI MAHMOUD. OXIDATIVE STRESS AND HYPERTENSION: POSSIBILITY OF HYPERTENSION THERAPY WITH ANTIOXIDANTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;19(4):358-367. Available from: https://sid.ir/paper/640690/en

IEEE: Copy

AZAR BARADARAN, HAMID NASRI, and MAHMOUD RAFIEIAN KOPAEI, “OXIDATIVE STRESS AND HYPERTENSION: POSSIBILITY OF HYPERTENSION THERAPY WITH ANTIOXIDANTS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 19, no. 4, pp. 358–367, 2014, [Online]. Available: https://sid.ir/paper/640690/en

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