DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD

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HEIDARI AMIR; AKBARI AZAM; PEIROUVI TAHMINEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Studies in Medical Sciences Year:2013 | Volume:24 | Issue:6 Page(s): 405-413

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Title

DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD

Author(s)

HEIDARI AMIR | AKBARI AZAM | PEIROUVI TAHMINEH | Issue Writer Certificate

Keywords

DEXTROMETHORPHANQ3

PHARMACEUTICAL DOSAGE FORMQ2

HPLCQ2

Abstract

Background & Aims: Quality control is the most common function to test and measure material and product. Quality control of active ingredients in drug formulation is to control the quality of the products of a company and evaluate their stability. The purpose of this study was to determine the amount of DEXTROMETHORPHAN available in drug market of Iran.Materials & Methods: For this purpose different pharmaceutical formulations of DEXTROMETHORPHAN with different serial number preparations were purchased from the market. Based on their standard methods of extraction (USP Pharmacopeia) the active ingredient DEXTROMETHORPHAN was extracted and determined by using HPLC Colum. The method utilize fluorescence detector.Results: The results of this project on 40 commercial products were as follow: The respective forms of pharmaceutical tablets were 104-124%, drops 87-92%, simple syrup 91-119%, and syrup mixture 109-120% of labeled.Conclusion: The assay results obtained from forty commercially available formulations of tablet and syrup were more than the amounts declared which agree with the tolerances indicated by the USP pharmacopeia while the assay results for drops were less than the declared values.

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APA: Copy

HEIDARI, AMIR, AKBARI, AZAM, & PEIROUVI, TAHMINEH. (2013). DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 24(6), 405-413. SID. https://sid.ir/paper/64105/en

Vancouver: Copy

HEIDARI AMIR, AKBARI AZAM, PEIROUVI TAHMINEH. DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2013;24(6):405-413. Available from: https://sid.ir/paper/64105/en

IEEE: Copy

AMIR HEIDARI, AZAM AKBARI, and TAHMINEH PEIROUVI, “DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 24, no. 6, pp. 405–413, 2013, [Online]. Available: https://sid.ir/paper/64105/en

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