STUDY OF PREVENTIVE EFFECTS OF COPPER ON ALUMINUM TOXICITY ON LIPID METABOLISM RELATED PARAMETERS IN RATS

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ANI M.; MOSHTAGHI A.A.; MAHMUDI L.; ANI A.R.

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Journal: Studies in Medical Sciences Year:2007 | Volume:17 | Issue:4 Page(s): 260-267

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Title

STUDY OF PREVENTIVE EFFECTS OF COPPER ON ALUMINUM TOXICITY ON LIPID METABOLISM RELATED PARAMETERS IN RATS

Author(s)

ANI M. | MOSHTAGHI A.A. | MAHMUDI L. | ANI A.R. | Issue Writer Certificate

Keywords

ALUMINUMQ3

COPPERQ3

LIPID METABOLISMQ3

Abstract

Background & Aims: It has been reported that the metabolism of lipids is affected in chronic renal failure patients undergoing hemodialysis. These patients show high levels of ALUMINUM in their blood which may be considered a casual factor for this alteration. COPPER is also a trace metal with diverse clinical uses and biochemical activities. For example, lack of COPPER leads to many adverse effects such as hypercholesterolemia. This study was undertaken to investigate if COPPER has any protective effects on the compensation of ALUMINUM toxicity.Materials & Methods: Adult male Wistar rats (200-250 gr) were divided into 3 experimental groups (Cu, Al, Al+Cu) and a control group which received one after another COPPER and ALUMINUM as chlorid salts and normal saline during the periods of 15 (Al: 15mg/kg, Cu: 1.5mg/kg), 30 (Al: 5mg/kg, Cu:1.5 mg/kg) and 60 (Al 1 mg/kg, Cu 0.1 mg/kg) days, daily, via intraperitoneal injection. The concentration of triglyceride, cholesterol, HDL, VLDL, fatty acids, the activity of LPL and also the amount of liver lipids were measured and compared with the control group.Results: ALUMINUM decreased TG in the acute phase. The simultaneous injection of COPPER could change this decrease from 69.23% into 35.38%. Fatty acids which had an increase of 86.06% during the acute phase of ALUMINUM injection, decreased to 26.22% by using COPPER at the same time. The effect of COPPER on the activity of LPL was considerable. During the acute phase, ALUMINUM caused an increase of 84.1% in the activity of this enzyme but using COPPER reversed this increase to 36.4%. These effects are not so significant in the chronic period which is probably caused by lack of COPPER dose in this period.Discussion: The results show that COPPER, to some extent, can moderate the toxicity of ALUMINUM on lipid parameters. These effects may be mediated by changing the intracellular level of cAMP and also affecting LPL activity.

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APA: Copy

ANI, M., MOSHTAGHI, A.A., MAHMUDI, L., & ANI, A.R.. (2007). STUDY OF PREVENTIVE EFFECTS OF COPPER ON ALUMINUM TOXICITY ON LIPID METABOLISM RELATED PARAMETERS IN RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(4), 260-267. SID. https://sid.ir/paper/64181/en

Vancouver: Copy

ANI M., MOSHTAGHI A.A., MAHMUDI L., ANI A.R.. STUDY OF PREVENTIVE EFFECTS OF COPPER ON ALUMINUM TOXICITY ON LIPID METABOLISM RELATED PARAMETERS IN RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2007;17(4):260-267. Available from: https://sid.ir/paper/64181/en

IEEE: Copy

M. ANI, A.A. MOSHTAGHI, L. MAHMUDI, and A.R. ANI, “STUDY OF PREVENTIVE EFFECTS OF COPPER ON ALUMINUM TOXICITY ON LIPID METABOLISM RELATED PARAMETERS IN RATS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 4, pp. 260–267, 2007, [Online]. Available: https://sid.ir/paper/64181/en

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