THE EFFECTS OF FOLIC ACID ON TRATOGENIC SIDE EFFECTS OF VALPROIC ACID IN NEURAL TUBE DEVELOPMENT OF MOUSE EMBRYOS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARI MPOUR M.; JAVANMARD M.; YEKTA Z.; DADMEHR F.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2007 | Volume:17 | Issue:4 Page(s): 298-303

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

863

Download:

Cites:

Information Journal Paper

Title

THE EFFECTS OF FOLIC ACID ON TRATOGENIC SIDE EFFECTS OF VALPROIC ACID IN NEURAL TUBE DEVELOPMENT OF MOUSE EMBRYOS

Author(s)

KARI MPOUR M. | JAVANMARD M. | YEKTA Z. | DADMEHR F. | Issue Writer Certificate

Keywords

VALPROIC ACIDQ4

NEURAL TUBEQ4

FOLIC ACIDQ3

MOUSE EMBRYOQ4

Abstract

Introduction: VALPROIC ACID is an anticonvulsant drug and its consumption in pregnancy leads to NEURAL TUBE defects. The aim of this study is to investigate the effects of FOLIC ACID in preventing teratogenic effects of VALPROIC ACID in MOUSE EMBRYOs.Materials and Methods: In this experimental study 30 female mice were included. The mice were divided in to three groups of control, experimental I and II.Mice in the group of experimental I received 200 mg/kg VALPROIC ACID and in group of experimental 11 received 200 mg/kg VALPROIC ACID and 4 mg/kg FOLIC ACID intraperitonealy on the 8th day of gestation. On the 13th day of gestation, the fetus was removed from uterine and their weight and height were measured and then kept in fixation. Finally, the specimen was examined microscopically.Results: The results showed that the weight and height in the experimental I significantly decreased in comparison to other groups (p<0/05). The rate of embryo absorption in the group of experimental I was more than other groups. Microscopic evidence showed some changes in neuroepithelial layer and also NEURAL TUBE defect in experimental I.Conclusion: Results showed that FOLIC ACID can prevent teratogenic effects of VALPROIC ACID in embryos whose mothers were exposed to VALPROIC ACID.

Cites

No record.

References

No record.

Cite

APA: Copy

KARI MPOUR, M., JAVANMARD, M., YEKTA, Z., & DADMEHR, F.. (2007). THE EFFECTS OF FOLIC ACID ON TRATOGENIC SIDE EFFECTS OF VALPROIC ACID IN NEURAL TUBE DEVELOPMENT OF MOUSE EMBRYOS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(4), 298-303. SID. https://sid.ir/paper/64188/en

Vancouver: Copy

KARI MPOUR M., JAVANMARD M., YEKTA Z., DADMEHR F.. THE EFFECTS OF FOLIC ACID ON TRATOGENIC SIDE EFFECTS OF VALPROIC ACID IN NEURAL TUBE DEVELOPMENT OF MOUSE EMBRYOS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2007;17(4):298-303. Available from: https://sid.ir/paper/64188/en

IEEE: Copy

M. KARI MPOUR, M. JAVANMARD, Z. YEKTA, and F. DADMEHR, “THE EFFECTS OF FOLIC ACID ON TRATOGENIC SIDE EFFECTS OF VALPROIC ACID IN NEURAL TUBE DEVELOPMENT OF MOUSE EMBRYOS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 4, pp. 298–303, 2007, [Online]. Available: https://sid.ir/paper/64188/en

Related Journal Papers