COMPARISON OF THE EFFECTIVENESS OF INTRAVENOUS MIDAZOLAM WITH ONDANSETRON ON NAUSEA AND VOMITING IN CESAREAN SECTIONS WITH SPINAL ANESTHESIA

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SANE SHAHRYAR; MAHOORI ALIREZA; KARAMI NAZLI; REZAEI HEDYE; REZAPOUR MAHSA

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Journal: Studies in Medical Sciences Year:2017 | Volume:28 | Issue:3 Page(s): 155-162

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Title

COMPARISON OF THE EFFECTIVENESS OF INTRAVENOUS MIDAZOLAM WITH ONDANSETRON ON NAUSEA AND VOMITING IN CESAREAN SECTIONS WITH SPINAL ANESTHESIA

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Keywords

ONDANSETRONQ1

MIDAZOLAMQ3

CESAREANQ3

NAUSEAQ2

VOMITINGQ2

SPINAL ANESTHESIAQ3

Abstract

Background & Aims: NAUSEA and VOMITING during SPINAL ANESTHESIA for elective CESAREAN delivery is a common finding and may occur in up to 80% of patients. The aim of the present study was to compare efficacy of using intravenous MIDAZOLAM alone, ONDANSETRON, and MIDAZOLAM in combination with ONDANSETRON for prevention of NAUSEA and VOMITING during and after CESAREAN delivery in parturient that underwent SPINAL ANESTHESIA.Materials & Methods: In a double-blind study, 126 women undergoing elective caesarean section under SPINAL ANESTHESIA (using 0.5% bupivacaine 12.5 mg) were allocated randomly to receive MIDAZOLAM 2 mg (n=42), ONDANSETRON 4 mg (n=42) or MIDAZOLAM and ONDANSETRON (n=42) after the clamping umbilical cord. The frequency of NAUSEA and VOMITING during and after surgery in recovery room were recorded.Results: The frequency of intraoperative NAUSEA and VOMITING was lower in the O (28.6, 7.1%) and MO (26.2, 16.7%) groups compared with M (50, 31%) group (P=0.04, P=0.006). The frequency of NAUSEA and VOMITING after surgery in recovery room was lower in the O (4.8, 19 %) and MO (11.9, 7.1%) groups compared with M (38.1, 23, 8 %) group (P=0.01, P=0.03). Metoclopramide consumption was lower in O and MO groups compared with M group (P=0.02). There was no difference in mean arterial pressure and pulse rate between three groups during the surgery at times measured.Conclusion: A bolus dose of MIDAZOLAM (2 mg) was not effective than ONDANSETRON (4mg) and ONDANSETRON plus MIDAZOLAM (O 4 and M 2 mg) for the prevention of NAUSEA and VOMITING in parturient patients undergoing CESAREAN section with SPINAL ANESTHESIA during and after surgery in recovery room; however, further studies are needed.

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APA: Copy

SANE, SHAHRYAR, MAHOORI, ALIREZA, KARAMI, NAZLI, REZAEI, HEDYE, & REZAPOUR, MAHSA. (2017). COMPARISON OF THE EFFECTIVENESS OF INTRAVENOUS MIDAZOLAM WITH ONDANSETRON ON NAUSEA AND VOMITING IN CESAREAN SECTIONS WITH SPINAL ANESTHESIA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 28(3), 155-162. SID. https://sid.ir/paper/64199/en

Vancouver: Copy

SANE SHAHRYAR, MAHOORI ALIREZA, KARAMI NAZLI, REZAEI HEDYE, REZAPOUR MAHSA. COMPARISON OF THE EFFECTIVENESS OF INTRAVENOUS MIDAZOLAM WITH ONDANSETRON ON NAUSEA AND VOMITING IN CESAREAN SECTIONS WITH SPINAL ANESTHESIA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2017;28(3):155-162. Available from: https://sid.ir/paper/64199/en

IEEE: Copy

SHAHRYAR SANE, ALIREZA MAHOORI, NAZLI KARAMI, HEDYE REZAEI, and MAHSA REZAPOUR, “COMPARISON OF THE EFFECTIVENESS OF INTRAVENOUS MIDAZOLAM WITH ONDANSETRON ON NAUSEA AND VOMITING IN CESAREAN SECTIONS WITH SPINAL ANESTHESIA,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 28, no. 3, pp. 155–162, 2017, [Online]. Available: https://sid.ir/paper/64199/en

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