THE CYTOTOXIC EFFECTS OF FRACTIONS ISOLATED FROM PLEUROTUS FLORIDA BODY EXTRACT ON CANCER CELL LINES

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GHAZANFARI TUBA; ZAMANI TAGHIZADE RABE SHAHRZAD; YARAYI ROYA; SIYADAT ZAHRA; MAHMOODI MAHMOUD

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Journal: Studies in Medical Sciences Year:2010 | Volume:21 | Issue:1 Page(s): 54-60

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Title

THE CYTOTOXIC EFFECTS OF FRACTIONS ISOLATED FROM PLEUROTUS FLORIDA BODY EXTRACT ON CANCER CELL LINES

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Keywords

PLEUROTUS FLORIDAQ3

CANCER CELL LINESQ3

CYTOTOXICITYQ3

Abstract

Background & Aim: Nowadays, different medical approaches are used for the treatment of cancers, but in most cases they are not effective or have serious side-effects. This has prompted scientists to look for more effective drugs with less toxicity. This study was to evaluate the cell CYTOTOXICITY effect of fractions isolated from PLEUROTUS FLORIDA on CANCER CELL LINES.Materials & Methods: R5, F5, R10, R30 and R100 fractions were isolated from PLEUROTUS FLORIDA body extract. The growth inhibitory activity of these fractions was determined for different CANCER CELL LINES using colorimetric MTT assay.Results: Results showed that isolated fractions showed significant inhibitory activity for CANCER CELL LINES in a dose-dependent manner. Some of the fractions such as R100 and R30 exhibited more inhibitory activity against HT-29. Among the tested cell lines, HT-29 was very sensitive to these fractions.Conclusion: Isolated fractions particularly R100 fraction from PLEUROTUS FLORIDA body extract showed cytotoxic effect on CANCER CELL LINES. So, they could be studied as anti-cancer agents in tumor-bearing animal models and subsequently in clinical trials for cancer patients. Further studies are needed to elucidate the mechanisms by which R100 fraction act.

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APA: Copy

GHAZANFARI, TUBA, ZAMANI TAGHIZADE RABE, SHAHRZAD, YARAYI, ROYA, SIYADAT, ZAHRA, & MAHMOODI, MAHMOUD. (2010). THE CYTOTOXIC EFFECTS OF FRACTIONS ISOLATED FROM PLEUROTUS FLORIDA BODY EXTRACT ON CANCER CELL LINES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 21(1), 54-60. SID. https://sid.ir/paper/64204/en

Vancouver: Copy

GHAZANFARI TUBA, ZAMANI TAGHIZADE RABE SHAHRZAD, YARAYI ROYA, SIYADAT ZAHRA, MAHMOODI MAHMOUD. THE CYTOTOXIC EFFECTS OF FRACTIONS ISOLATED FROM PLEUROTUS FLORIDA BODY EXTRACT ON CANCER CELL LINES. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2010;21(1):54-60. Available from: https://sid.ir/paper/64204/en

IEEE: Copy

TUBA GHAZANFARI, SHAHRZAD ZAMANI TAGHIZADE RABE, ROYA YARAYI, ZAHRA SIYADAT, and MAHMOUD MAHMOODI, “THE CYTOTOXIC EFFECTS OF FRACTIONS ISOLATED FROM PLEUROTUS FLORIDA BODY EXTRACT ON CANCER CELL LINES,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 21, no. 1, pp. 54–60, 2010, [Online]. Available: https://sid.ir/paper/64204/en

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