CHANGES IN HRCT SPIROMETRY AND CLINICAL SYMPTOM IN SCLERODERMA PATIENTS’ TREATMENT WITH INTRAVENOUS CYCLOPHOSPHAMIDE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJIALILO MEHRZAD; TAGHIZADEIEH ALI; KHABBAZI ALIREZA; GHORBANIHAGHJO AMIR; ASADZADEH MINA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2016 | Volume:27 | Issue:6 Page(s): 466-475

Download Full-Text

Persian Verion

View:

1,108

Download:

Cites:

Information Journal Paper

Title

CHANGES IN HRCT SPIROMETRY AND CLINICAL SYMPTOM IN SCLERODERMA PATIENTS’ TREATMENT WITH INTRAVENOUS CYCLOPHOSPHAMIDE

Author(s)

Keywords

SCLERODERMAQ2

LUNG DISEASEQ2

CYCLOPHOSPHAMIDEQ2

Abstract

Background & Aims: SCLERODERMA is a systemic condition with various manifestations in different organs. Among these organs, the lungs are affected very frequently, and the involvement is progressive and significant. Various medications have been suggested and tested in patients with SCLERODERMA and lung involvement, but their efficacy and safety profile differ and enforce a difficult final decisionmaking.Since CYCLOPHOSPHAMIDE is an example of this kind, this study sought to examine the therapeutic effect of this drug in patients with SCLERODERMA and LUNG DISEASE.Materials & Methods: A total of 20 patients with SCLERODERMA and lung parenchymal disease received intravenous CYCLOPHOSPHAMIDE (750 mg/m2) along with gradually tapering prednisolone (20-7.5 mg/day) and azathioprine (2mg/kg) after discontinuation of the former for six consecutive months. The Transition Dyspnea Index (TDI), Forced Vital Capacity (FVC), Total Lung Capacity (TLC), 17 revised Rodnan Score were examined three and six months after starting the treatment.Results: Six months after treatment, significant changes in FVC (p=0.55), TLC (p=0.39), FEV1 (p=0.27), 17 revised Rodnan Score (p=0.98) was not observed. The TDI also did not show significant changes during the six months of treatment (p=0.79). Based on the type of antibody was not seen significant difference in the amount of TDI.Conclusion: Administration of intravenous CYCLOPHOSPHAMIDE in the treatment of SCLERODERMA in patients with pulmonary involvement of our study did not have considerable effects on pulmonary function and clinical manifestations that were similar to other studies in this field.

Cites

No record.

References

No record.

Cite

APA: Copy

HAJIALILO, MEHRZAD, TAGHIZADEIEH, ALI, KHABBAZI, ALIREZA, GHORBANIHAGHJO, AMIR, & ASADZADEH, MINA. (2016). CHANGES IN HRCT SPIROMETRY AND CLINICAL SYMPTOM IN SCLERODERMA PATIENTS’ TREATMENT WITH INTRAVENOUS CYCLOPHOSPHAMIDE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(6), 466-475. SID. https://sid.ir/paper/64214/en

Vancouver: Copy

HAJIALILO MEHRZAD, TAGHIZADEIEH ALI, KHABBAZI ALIREZA, GHORBANIHAGHJO AMIR, ASADZADEH MINA. CHANGES IN HRCT SPIROMETRY AND CLINICAL SYMPTOM IN SCLERODERMA PATIENTS’ TREATMENT WITH INTRAVENOUS CYCLOPHOSPHAMIDE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2016;27(6):466-475. Available from: https://sid.ir/paper/64214/en

IEEE: Copy

MEHRZAD HAJIALILO, ALI TAGHIZADEIEH, ALIREZA KHABBAZI, AMIR GHORBANIHAGHJO, and MINA ASADZADEH, “CHANGES IN HRCT SPIROMETRY AND CLINICAL SYMPTOM IN SCLERODERMA PATIENTS’ TREATMENT WITH INTRAVENOUS CYCLOPHOSPHAMIDE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 6, pp. 466–475, 2016, [Online]. Available: https://sid.ir/paper/64214/en

Related Journal Papers