A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE IN PAP. SMEARS FOLLOWED BY BIOPSY RESULTS FOR DETERMINATION OF RELIABLE CYTOLOGIC PARAMETERS

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ABBASI F.; GHAVAM F.; NOROUZINIA F.; POURALI R.; JALVAND M.

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Journal: Studies in Medical Sciences Year:2004 | Volume:15 | Issue:3 Page(s): 196-200

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Title

A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE IN PAP. SMEARS FOLLOWED BY BIOPSY RESULTS FOR DETERMINATION OF RELIABLE CYTOLOGIC PARAMETERS

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Keywords

PAP SMEARQ3

ASCUSQ4

REACTIVE CHANGEQ4

DYSPLASIAQ3

S.C.CQ4

Abstract

Introduction: Microscopic evaluation of cervicovaginal smears (PAP SMEAR) plays an essential role in detection of the preneoplastic and neoplastic lesions of uterine cervix. A wide spectrum of changes are seen in PAP SMEARs. Interpretation of intermediate changes which resulting in observation of so-called ASCUS is difficult. ASCUS is defined as a cellular change that is more marked than typical REACTIVE CHANGE but lack features diagnostic of intraepithelial neoplasia. Different studies revealed that in 30%-40% of cases with ASCUS in PAP SMEAR, DYSPLASIA was seen in biopsy sample.The aim of this study was determination of reliable cytologic parameters to identifying real nature of ASCUS.Methods: In this near 4 years investigation, all PAP SMEARs with presence of ASCUS which followed by biopsy samples were reviewed. In this regard 17 parameters of cytoplasm, nuclei and smear background were considered and the datas analysed by SPSS and Chi Square test.Results: After statistical evaluation, we found that 4 parameters of irregular nuclear contour, increased nucleo-cytoplasmic ratio, cytoplasmic vacuolization and dirty background are highly suggestive of DYSPLASIA.Discussion: It is important to consider that to find out the real nature of ASCUS a group of parameters are more helpful than a single one. Also, a single PAP SMEAR is not enough for this purpose and further investigation is required.

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APA: Copy

ABBASI, F., GHAVAM, F., NOROUZINIA, F., POURALI, R., & JALVAND, M.. (2004). A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE IN PAP. SMEARS FOLLOWED BY BIOPSY RESULTS FOR DETERMINATION OF RELIABLE CYTOLOGIC PARAMETERS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 15(3), 196-200. SID. https://sid.ir/paper/64240/en

Vancouver: Copy

ABBASI F., GHAVAM F., NOROUZINIA F., POURALI R., JALVAND M.. A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE IN PAP. SMEARS FOLLOWED BY BIOPSY RESULTS FOR DETERMINATION OF RELIABLE CYTOLOGIC PARAMETERS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2004;15(3):196-200. Available from: https://sid.ir/paper/64240/en

IEEE: Copy

F. ABBASI, F. GHAVAM, F. NOROUZINIA, R. POURALI, and M. JALVAND, “A COMPARATIVE STUDY OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE IN PAP. SMEARS FOLLOWED BY BIOPSY RESULTS FOR DETERMINATION OF RELIABLE CYTOLOGIC PARAMETERS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 15, no. 3, pp. 196–200, 2004, [Online]. Available: https://sid.ir/paper/64240/en

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