ASSOCIATION OF CHEMOKINE CCL2 GENE POLYMORPHISM WITH HENOCHE SCHONLEIN PURPURA DISEASE IN NORTHWEST OF IRAN

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BONYADI MORTAZA; MOHAMMADIAN TAHEREH; RAFEEY MANDANA; SADEGHI SHABESTARI MAHNAZ; MORTAZAVI FAKHROSSADAT

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Journal: Studies in Medical Sciences Year:2014 | Volume:25 | Issue:11 Page(s): 998-1004

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Title

ASSOCIATION OF CHEMOKINE CCL2 GENE POLYMORPHISM WITH HENOCHE SCHONLEIN PURPURA DISEASE IN NORTHWEST OF IRAN

Author(s)

Keywords

HENOCH SCHONLEIN PURPURAQ3

CYTOKINESQ2

POLYMORPHISMQ2

VASCULITISQ3

CCL2Q2

Abstract

Background & Aims: Henoch–Schonlein purpura (HSP) is an autoinflammatory disease and systemic small vessel VASCULITIS that more frequently occurs in children. It is characterized by skin lesion such as Petechia and purpura, gasterointestinal involvement including abdominal pain and gastrointestinal bleeding and arthiritis. Studies have shown that HSP could be due to different infections and genetic factors. Based on the fact that CYTOKINES have important role in this inflammatory disease, CCL2- a chemokine encoding gene- is studied in HSP patients from northwestern Iran. To achieve this goal molecular analysis of POLYMORPHISM located in promoter region of this gene is performed.Materials & Methods: This study was conducted on 40 HSP patients who were referred by immunology and allergy specialists to Genetic Center of Tabriz and after blood sampling and DNA extraction, molecular analysis with PCR-RFLP method was performed to genotype polymorphic region of promoter region of this gene. The results were compared to that of 50 ethnic-sex matched control healthy people.Results: Statistical analysis shows significant association of this POLYMORPHISM with development of Henoch–Schonlein purpura disease in this cohort. The frequency of TT and TC genotypes and T allele of CCL2 -C2518T gene POLYMORPHISM were significantly higher in HSP patients.Conclusion: CCL2 C-2518T gene POLYMORPHISMs were associated with susceptibility to HSP in Northwestern Iran.

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APA: Copy

BONYADI, MORTAZA, MOHAMMADIAN, TAHEREH, RAFEEY, MANDANA, SADEGHI SHABESTARI, MAHNAZ, & MORTAZAVI, FAKHROSSADAT. (1393). همراهی پلی مورفیسم ژن CCL2 با استعداد ابتلا به بیماری هنوخ شوئن لاین در جمعیت شمال غرب ایران. مجله مطالعات علوم پزشکی (مجله پزشکی دانشگاه علوم پزشکی ارومیه), 25(11), 998-1004. SID. https://sid.ir/paper/64256/en

Vancouver: Copy

BONYADI MORTAZA, MOHAMMADIAN TAHEREH, RAFEEY MANDANA, SADEGHI SHABESTARI MAHNAZ, MORTAZAVI FAKHROSSADAT. همراهی پلی مورفیسم ژن CCL2 با استعداد ابتلا به بیماری هنوخ شوئن لاین در جمعیت شمال غرب ایران. مجله مطالعات علوم پزشکی (مجله پزشکی دانشگاه علوم پزشکی ارومیه)[Internet]. 1393;25(11):998-1004. Available from: https://sid.ir/paper/64256/en

IEEE: Copy

MORTAZA BONYADI, TAHEREH MOHAMMADIAN, MANDANA RAFEEY, MAHNAZ SADEGHI SHABESTARI, and FAKHROSSADAT MORTAZAVI, “همراهی پلی مورفیسم ژن CCL2 با استعداد ابتلا به بیماری هنوخ شوئن لاین در جمعیت شمال غرب ایران,” مجله مطالعات علوم پزشکی (مجله پزشکی دانشگاه علوم پزشکی ارومیه), vol. 25, no. 11, pp. 998–1004, 1393, [Online]. Available: https://sid.ir/paper/64256/en

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