GENETIC VARIATIONS OF TUMOR NECROSIS FACTOR -α-308 AND LYMPHTOXIN--α+252 IN NON-HODGKIN LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS

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NASIRI HAJAR; FARAJNIA SAFAR; REZAMAND AZIM; MOVASSAGHPUOR ALI AKBAR; ESMAEILI HEYDAR ALI; MONFAREDAN AMIR; MOBARRA NASER; RAHIMIFAR NASSER; SAHEBI LEILA; FARSHDOUSTI HAGH MAJID

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Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:9 Page(s): 990-995

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Title

GENETIC VARIATIONS OF TUMOR NECROSIS FACTOR -α-308 AND LYMPHTOXIN--α+252 IN NON-HODGKIN LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS

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Keywords

ACUTE LYMPHOCYTIC LEUKE- MIA

LT-α

NON-HODGKIN LYMPHOMA

POLYMORPHISM

TNF-α

Abstract

Objective (s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic POLYMORPHISMs in tumor necrosis factor-a (TNF-a) -308 and lymphotoxin-a (LT-a) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-a (-308) and LT-a (+252) POLYMORPHISMs are different for NHL and ALL cases in various populations with different ethnicity. This research is designed to investigate the prevalence and association of TNF-a (-308) and LT-a (+252) POLYMORPHISMs from NHL and ALL in Azarian patients and healthy individuals from Northwestern part of Iran.Materials and Methods: Seventy subjects with ALL and 68 NHL, along with another 130 healthy subjects as control group took part in this study. Genomic DNA was extracted, then genetic POLYMORPHISMs in TNF-a and LT-a genes were analyzed with the PCR-RFLP and NCOI as restriction enzyme. A statistical analysis was performed by chi-square test using SPSS software. A P-value of<0.05 was considered statistically significant.Results: A statistically significant difference of LT-a POLYMORPHISM was in NHL patients and control (P-value=0.008) but there was not any association of TNF-a POLYMORPHISM between NHL patients and control group. A significant association for TNF-a variant was in ALL and control (P-value=0.005), however, there was no relationship about LT variant between ALL and control.Conclusion: The results show that there are significant differences between TNF-a (-308) and LT-a (+252) genetic POLYMORPHISMs respectively in ALL and NHL patients with control group from Northwestern part of Iran.

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APA: Copy

NASIRI, HAJAR, FARAJNIA, SAFAR, REZAMAND, AZIM, MOVASSAGHPUOR, ALI AKBAR, ESMAEILI, HEYDAR ALI, MONFAREDAN, AMIR, MOBARRA, NASER, RAHIMIFAR, NASSER, SAHEBI, LEILA, & FARSHDOUSTI HAGH, MAJID. (2013). GENETIC VARIATIONS OF TUMOR NECROSIS FACTOR -α-308 AND LYMPHTOXIN--α+252 IN NON-HODGKIN LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(9), 990-995. SID. https://sid.ir/paper/643477/en

Vancouver: Copy

NASIRI HAJAR, FARAJNIA SAFAR, REZAMAND AZIM, MOVASSAGHPUOR ALI AKBAR, ESMAEILI HEYDAR ALI, MONFAREDAN AMIR, MOBARRA NASER, RAHIMIFAR NASSER, SAHEBI LEILA, FARSHDOUSTI HAGH MAJID. GENETIC VARIATIONS OF TUMOR NECROSIS FACTOR -α-308 AND LYMPHTOXIN--α+252 IN NON-HODGKIN LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(9):990-995. Available from: https://sid.ir/paper/643477/en

IEEE: Copy

HAJAR NASIRI, SAFAR FARAJNIA, AZIM REZAMAND, ALI AKBAR MOVASSAGHPUOR, HEYDAR ALI ESMAEILI, AMIR MONFAREDAN, NASER MOBARRA, NASSER RAHIMIFAR, LEILA SAHEBI, and MAJID FARSHDOUSTI HAGH, “GENETIC VARIATIONS OF TUMOR NECROSIS FACTOR -α-308 AND LYMPHTOXIN--α+252 IN NON-HODGKIN LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 9, pp. 990–995, 2013, [Online]. Available: https://sid.ir/paper/643477/en

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