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Information Journal Paper

Title

THE EFFECTS OF SHILAJIT ON BRAIN EDEMA, INTRACRANIAL PRESSURE AND NEUROLOGIC OUTCOMES FOLLOWING THE TRAUMATIC BRAIN INJURY IN RAT

Pages

  858-864

Abstract

 Objective (s): BRAIN EDEMA is one of the most serious causes of death within the first few days after TRAUMA brain injury (TBI). In this study we have investigated the role of SHILAJIT on BRAIN EDEMA, blood-brain barrier (BBB) permeability, INTRACRANIAL PRESSURE (ICP) and neurologic outcomes following brain TRAUMA.Materials and Methods: Diffuse TRAUMAtic brain TRAUMA was induced in RATs by drop of a 250 g weight from a 2 m high (Marmarou’s methods). Animals were randomly divided into 5 groups including sham, TBI, TBI-vehicle, TBI-Shi150 group and TBI-Shi250 group. RATs were undergone intraperitoneal injection of SHILAJIT and vehicle at 1, 24, 48 and 72 hr after TRAUMA. Brain water content, BBB permeability, ICP and neurologic outcomes were finally measured.Results: Brain water and Evans blue dye contents showed significant decrease in SHILAJIT-treated groups compared to the TBI-vehicle and TBI groups. INTRACRANIAL PRESSURE at 24, 48 and 72 hr after TRAUMA had significant reduction in SHILAJIT-treated groups as compared to TBI-vehicle and TBI groups (P<0.001). The RATe of neurologic outcomes improvement at 4, 24, 48 and 72 hr after TRAUMA showed significant increase in SHILAJIT-treated groups in comparison to theTBI- vehicle and TBI groups (P<0.001).Conclusion: The present results indicated that SHILAJIT may cause in improvement of neurologic outcomes through decreasing BRAIN EDEMA, disrupting of BBB, and ICP after the TBI.

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    APA: Copy

    KHAKSARI, MOHAMMAD, MAHMMODI, REZA, SHAHROKHI, NADER, SHABANI, MOHAMMAD, JOUKAR, SIAVASH, & AQAPOUR, MOBIN. (2013). THE EFFECTS OF SHILAJIT ON BRAIN EDEMA, INTRACRANIAL PRESSURE AND NEUROLOGIC OUTCOMES FOLLOWING THE TRAUMATIC BRAIN INJURY IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(7), 858-864. SID. https://sid.ir/paper/643490/en

    Vancouver: Copy

    KHAKSARI MOHAMMAD, MAHMMODI REZA, SHAHROKHI NADER, SHABANI MOHAMMAD, JOUKAR SIAVASH, AQAPOUR MOBIN. THE EFFECTS OF SHILAJIT ON BRAIN EDEMA, INTRACRANIAL PRESSURE AND NEUROLOGIC OUTCOMES FOLLOWING THE TRAUMATIC BRAIN INJURY IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(7):858-864. Available from: https://sid.ir/paper/643490/en

    IEEE: Copy

    MOHAMMAD KHAKSARI, REZA MAHMMODI, NADER SHAHROKHI, MOHAMMAD SHABANI, SIAVASH JOUKAR, and MOBIN AQAPOUR, “THE EFFECTS OF SHILAJIT ON BRAIN EDEMA, INTRACRANIAL PRESSURE AND NEUROLOGIC OUTCOMES FOLLOWING THE TRAUMATIC BRAIN INJURY IN RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 7, pp. 858–864, 2013, [Online]. Available: https://sid.ir/paper/643490/en

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