PREPARATION AND CHARACTERIZATION OF CYANOCOBALAMIN (VIT B12) MICROEMULSION PROPERTIES AND STRUCTURE FOR TOPICAL AND TRANSDERMAL APPLICATION

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SALIMI ANAYATOLLAH; SHARIF MAKHMALZADEH BEHZAD; MOGHIMIPOUR ESKANDAR

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Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:7 Page(s): 865-872

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Title

PREPARATION AND CHARACTERIZATION OF CYANOCOBALAMIN (VIT B12) MICROEMULSION PROPERTIES AND STRUCTURE FOR TOPICAL AND TRANSDERMAL APPLICATION

Author(s)

SALIMI ANAYATOLLAH | SHARIF MAKHMALZADEH BEHZAD | MOGHIMIPOUR ESKANDAR | Issue Writer Certificate

Keywords

DSC

MICROEMULSION MICROSTRUCTURE

PSEUDO TERNARY PHASEDIAGRAM

SAXS

Abstract

Objective (s): The objective of this study was to design a topical microemulsion of Vit B12 and to study the correlation between internal structure and physicochemical properties of the microemulsions. Microemulsions are thermodynamically stable mixtures of water, oil, surfactants and usually cosurfactants with several advantages for topical and transdermal drug delivery. The formulation of microemulsions for pharmaceutical use requires a clear understanding of the properties and microstructures of the microemulsions.Materials and Methods: In this study, phase behavior and microstructure of traditional and novel microemulsions of Vit B12 have been investigated by Small-angle X-ray (SAXS), differential scanning calorimetery (DSC) and measuring density, particle size, conductivity and surface tension.Results: WO and bicontinuous microemulsion with different microstructures were found in novel and traditional formulations. In this study, amount of water, surfactant concentration, oil/ surfactant ratio and physicochemical properties of cosurfactants influenced the microstructures. In both formulations, water behavior was affected by the concentration of the surfactant. Water Solubilization capacity and enthalpy of exothermic peak of interfacial and free water of traditional formulations were more than novel ones. This means that the affinity of water to interfacial film is dependent on the surfactant properties.Conclusion: This study showed that both microemulsions provided good solubility of Vit B12 with a wide range of internal structure. Low water solubilization capacity is a common property of microemulsions that can affect drug release and permeability through the skin. Based on Vit B12 properties, specially, intermediate oil and water solubility, better drug partitioning into the skin may be obtained by traditional formulations with wide range of structure and high amount of free and bounded water.

Cites

PREPARATION AND MICROSTRUCTURAL CHARACTERIZATION OF GRISEOFULVIN MICROEMULSIONS USING DIFFERENT EXPERIMENTAL METHODS: SAXS AND DSC

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APA: Copy

SALIMI, ANAYATOLLAH, SHARIF MAKHMALZADEH, BEHZAD, & MOGHIMIPOUR, ESKANDAR. (2013). PREPARATION AND CHARACTERIZATION OF CYANOCOBALAMIN (VIT B₁₂) MICROEMULSION PROPERTIES AND STRUCTURE FOR TOPICAL AND TRANSDERMAL APPLICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(7), 865-872. SID. https://sid.ir/paper/643492/en

Vancouver: Copy

SALIMI ANAYATOLLAH, SHARIF MAKHMALZADEH BEHZAD, MOGHIMIPOUR ESKANDAR. PREPARATION AND CHARACTERIZATION OF CYANOCOBALAMIN (VIT B₁₂) MICROEMULSION PROPERTIES AND STRUCTURE FOR TOPICAL AND TRANSDERMAL APPLICATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(7):865-872. Available from: https://sid.ir/paper/643492/en

IEEE: Copy

ANAYATOLLAH SALIMI, BEHZAD SHARIF MAKHMALZADEH, and ESKANDAR MOGHIMIPOUR, “PREPARATION AND CHARACTERIZATION OF CYANOCOBALAMIN (VIT B₁₂) MICROEMULSION PROPERTIES AND STRUCTURE FOR TOPICAL AND TRANSDERMAL APPLICATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 7, pp. 865–872, 2013, [Online]. Available: https://sid.ir/paper/643492/en

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