THE EFFECT OF SALSALATE ON BIOCHEMICAL FACTORS AND ENDOTHELIAL DYSFUNCTION OF PREDIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

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FAKHRI MARYAM; FAGHIH IMANI ELHAM; KHALILI NOUSHIN

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:19 | Issue:4 Page(s): 287-292

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Title

THE EFFECT OF SALSALATE ON BIOCHEMICAL FACTORS AND ENDOTHELIAL DYSFUNCTION OF PREDIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

Author(s)

FAKHRI MARYAM | FAGHIH IMANI ELHAM | KHALILI NOUSHIN | Issue Writer Certificate

Keywords

DIABETES

ENDOTHELIAL FUNCTION

SALSALATE

Abstract

Background: The beneficial effect of using nonacetylated salicylates such as SALSALATE on decreasing the speed of DIABETES progression is a controversial issue. The aim of this study was to evaluate the effect of SALSALATE on metabolic-syndrome-associated parameters as well as the ENDOTHELIAL FUNCTION of diabetic and impaired glucose tolerance patients.Materials and Methods: Patients were collected from Isfahan endocrinology research center referrals. Patients with impaired glucose tolerance diagnosis or newly diagnosed DIABETES were enrolled in the study. Patients were randomized to receive 1.5 g SALSALATE (2×750 mg) BID or placebo twice a day for 3 months. After the mentioned period, all patients were recalled and complete examination was done; blood samples for biochemistry measurements were drawn (for measuring FBS, post prandial glucose, HbA1C, Total cholesterol, HDL, TG, LDL) and forearm flow-mediated dilation (FMD) was performed.Results: Forty patients were enrolled, 32 patients (80%) were female. Mean age of patients was 47.15±6.67 years. FBS (fasting blood sugar) was shown to be significantly different between intervention and control subjects before or after treatment. FMD increased significantly in the intervention group (P=0.004). Conclusion: The study showed that SALSALATE decreased FBS levels of patients. It may also improve ENDOTHELIAL FUNCTION as FMD increased significantly in the intervention group.

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APA: Copy

FAKHRI, MARYAM, FAGHIH IMANI, ELHAM, & KHALILI, NOUSHIN. (2014). THE EFFECT OF SALSALATE ON BIOCHEMICAL FACTORS AND ENDOTHELIAL DYSFUNCTION OF PREDIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(4), 287-292. SID. https://sid.ir/paper/644535/en

Vancouver: Copy

FAKHRI MARYAM, FAGHIH IMANI ELHAM, KHALILI NOUSHIN. THE EFFECT OF SALSALATE ON BIOCHEMICAL FACTORS AND ENDOTHELIAL DYSFUNCTION OF PREDIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;19(4):287-292. Available from: https://sid.ir/paper/644535/en

IEEE: Copy

MARYAM FAKHRI, ELHAM FAGHIH IMANI, and NOUSHIN KHALILI, “THE EFFECT OF SALSALATE ON BIOCHEMICAL FACTORS AND ENDOTHELIAL DYSFUNCTION OF PREDIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 19, no. 4, pp. 287–292, 2014, [Online]. Available: https://sid.ir/paper/644535/en

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