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Information Journal Paper

Title

COMPARISON OF THE EFFECTS OF ONDANSETRON, VITAMIN B6 AND GINGER RHIZOME IN NAUSEA AND VOMITING OF PREGNANCY: A RANDOMIZED CLINICAL TRIAL

Pages

  29-35

Abstract

 IntroductionNausea and VOMITING is one of common complications in pregnancy that not only affects the women's physical health, it can also have a negative impact on their psychological and social performance. Suggestions have been made to effect on the nausea and VOMITING of pregnancy. There are different methods to control the nausea and VOMITING of pregnancy. Therefore, this study was performed with aim to compare the effect of ONDANSETRON, VITAMIN B6 and GINGER RHIZOME on nausea and VOMITING in pregnancy. MethodsThis double-blinded randomized clinical trial was performed on 120 pregnant women with gestational age <16 weeks who had mild and moderate nausea and VOMITING referred to health centers of Hamadan in 2017. The samples were randomly divided in four groups of 30 cases: ONDANSETRON (4 mg), VITAMIN B6 (40 mg), GINGER RHIZOME (250 mg), and placebo groups, two times per day for one week. Severity of nausea and VOMITING was assessed before and after the study by nausea and VOMITING questionnaires (PUQE). Data was analyzed by SPSS software (version 21) and using chi-square, paired t-tests and ANOVA. P <0. 05 was considered significant. Resultsbefore the intervention, no significant difference was found in the four groups in the score of PREGNANCY NAUSEA and VOMITING (p=1. 00). After the intervention, according to ANOVA test, the score of nausea and VOMITING was significantly different between the ONDANSETRON, VITAMIN B6 and GINGER RHIZOME groups with placebo group (p<0. 001). According to paired t-test, severity and duration of nausea and VOMITING was significantly reduced in three treatments groups (p<0. 001), and this decrease was less and significant in the ginger root group (P<0. 001). ConclusionGINGER RHIZOME like as ONDANSETRON and VITAMIN B6 can reduce the severity and duration of nausea and VOMITING; therefore its use in pregnant women can be helpful.

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    APA: Copy

    NAZARI, SASAN, NAZARI, SAMAN, SHAYAN, AREZOO, SHOBEIRI, FATEMEH, & AHMADI NIYATABESH, ROYA. (2018). COMPARISON OF THE EFFECTS OF ONDANSETRON, VITAMIN B6 AND GINGER RHIZOME IN NAUSEA AND VOMITING OF PREGNANCY: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 21(7 ), 29-35. SID. https://sid.ir/paper/64530/en

    Vancouver: Copy

    NAZARI SASAN, NAZARI SAMAN, SHAYAN AREZOO, SHOBEIRI FATEMEH, AHMADI NIYATABESH ROYA. COMPARISON OF THE EFFECTS OF ONDANSETRON, VITAMIN B6 AND GINGER RHIZOME IN NAUSEA AND VOMITING OF PREGNANCY: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2018;21(7 ):29-35. Available from: https://sid.ir/paper/64530/en

    IEEE: Copy

    SASAN NAZARI, SAMAN NAZARI, AREZOO SHAYAN, FATEMEH SHOBEIRI, and ROYA AHMADI NIYATABESH, “COMPARISON OF THE EFFECTS OF ONDANSETRON, VITAMIN B6 AND GINGER RHIZOME IN NAUSEA AND VOMITING OF PREGNANCY: A RANDOMIZED CLINICAL TRIAL,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 21, no. 7 , pp. 29–35, 2018, [Online]. Available: https://sid.ir/paper/64530/en

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