EVALUATION OF THE T HELPER 17 CELL SPECIFIC GENES AND THE INNATE LYMPHOID CELLS COUNTS IN THE PERIPHERAL BLOOD OF PATIENTS WITH THE COMMON VARIABLE IMMUNODEFICIENCY

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GANJALIKHANI HAKEMI MAZDAK; YAZDANI REZA; SHERKAT ROYA; HOMAYOUNI VIDA; MASJEDI MOHSEN; HOSSEINI MOHSEN

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:19 | Issue:SUPPLEMENT 1 Page(s): 30-35

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Title

EVALUATION OF THE T HELPER 17 CELL SPECIFIC GENES AND THE INNATE LYMPHOID CELLS COUNTS IN THE PERIPHERAL BLOOD OF PATIENTS WITH THE COMMON VARIABLE IMMUNODEFICIENCY

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Keywords

COMMON VARIABLE IMMUNODEFICIENCY

INNATE LYMPHOID CELLS

INTERLEUKIN 9

INTERLEUKIN 17

INTERLEUKIN 23R

T HELPER 17 CELLS

Abstract

Background: COMMON VARIABLE IMMUNODEFICIENCY (CVID) is characterized by a deficiency in the immune system with a heterogeneous collection of disorders resulting in antibody deficiency and recurrent infections. T helper 17 (Th 17) cells promote B-cell survival and synergize with the B-cell activating factor to induce their differentiation into the plasma cells. A sub-population of INNATE LYMPHOID CELLS (ILCs) also produces INTERLEUKIN 17 (IL-17). This study aimed to measure the Th 17 specific genes and ILCs counts in the CVID patients in comparison with control subjects.Materials and Methods: Total messenger ribonucleic acid (mRNA) was extracted from the whole blood samples of 10 CVID patients and 10 healthy individuals. IL-17, retinoic acid receptor-related orphan receptor C2 (RORC2), IL-23R, and IL-9 gene expression were measured using the quantitative reverse transcriptase-polymerase chain reaction. Count of lineage negative/CD127+/CD90+ ILCs in the blood samples was performed by the flow cytometry method.Results: The transcript levels of IL-17 and RORC2 in CVID patients was strongly lower than control subjects (P=0.049 and P=0.046, respectively), but slight reduction in the IL-23R expression (P=0.252) have seen in the CVID patients. Accordingly, the number of ILCs decreased significantly (P=0.04). Interestingly, IL-9 mRNA level was more significantly in the CVID patients (P=0.001).Conclusion: The results presented in this study show that the Th 17 cell specific genes expression (as the determiner Th 17 cells) and ILCs (another lymphoid source of IL-17) are decreased in patients with CVID and this could be an explanation for the defect of their humoral immune response. In addition, elevation of the IL-9 gene expression may shed a new light into the way toward the understanding of the mechanism of autoimmunity in the CVID patients.

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IMPORTANT FACTORS INFLUENCING SEVERITY OF COMMON VARIABLE IMMUNODEFICIENCY

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APA: Copy

GANJALIKHANI HAKEMI, MAZDAK, YAZDANI, REZA, SHERKAT, ROYA, HOMAYOUNI, VIDA, MASJEDI, MOHSEN, & HOSSEINI, MOHSEN. (2014). EVALUATION OF THE T HELPER 17 CELL SPECIFIC GENES AND THE INNATE LYMPHOID CELLS COUNTS IN THE PERIPHERAL BLOOD OF PATIENTS WITH THE COMMON VARIABLE IMMUNODEFICIENCY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(SUPPLEMENT 1), 30-35. SID. https://sid.ir/paper/645695/en

Vancouver: Copy

GANJALIKHANI HAKEMI MAZDAK, YAZDANI REZA, SHERKAT ROYA, HOMAYOUNI VIDA, MASJEDI MOHSEN, HOSSEINI MOHSEN. EVALUATION OF THE T HELPER 17 CELL SPECIFIC GENES AND THE INNATE LYMPHOID CELLS COUNTS IN THE PERIPHERAL BLOOD OF PATIENTS WITH THE COMMON VARIABLE IMMUNODEFICIENCY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;19(SUPPLEMENT 1):30-35. Available from: https://sid.ir/paper/645695/en

IEEE: Copy

MAZDAK GANJALIKHANI HAKEMI, REZA YAZDANI, ROYA SHERKAT, VIDA HOMAYOUNI, MOHSEN MASJEDI, and MOHSEN HOSSEINI, “EVALUATION OF THE T HELPER 17 CELL SPECIFIC GENES AND THE INNATE LYMPHOID CELLS COUNTS IN THE PERIPHERAL BLOOD OF PATIENTS WITH THE COMMON VARIABLE IMMUNODEFICIENCY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 19, no. SUPPLEMENT 1, pp. 30–35, 2014, [Online]. Available: https://sid.ir/paper/645695/en

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