مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PANTOPRAZOLE, A PROTON PUMP INHIBITOR, INCREASES ORTHODONTIC TOOTH MOVEMENT IN RATS

Pages

  448-453

Abstract

 Objective(s): PANTOPRAZOLE, is a proton pump inhibitor (PPI) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. The aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic TOOTH MOVEMENT (OTM) in RATS.Materials and Methods: A time course study was established using 72 RATS which were divided into six groups of 12 samples each (four: vehicle; eight: PANTOPRAZOLE + vehicle). PANTOPRAZOLE at a dose of 200 mg/kg suspended in carboxymethyl cellulose (0.25 percent) was administered by a gastric tube. The upper incisors and first molars were ligated by a 5 mm nickel-titanium closed-coil spring to deliver an initial force of 60 g. Animals were euthanized two weeks after orthodontic treatment followed by assessment of TOOTH MOVEMENT and histomorphometric evaluation of the detached maxillae. Lateral skull radiographs were obtained once a week, starting from the first day to the 6th week of the study. OTM and bone density data were analyzed using independent sample t-test and repeated measures ANOVA.Results: No significant changes in OTM measurements and optical density were observed in vehicle-receiving animals during the study (P=0.994). OTM was significantly increased after six weeks PANTOPRAZOLE therapy which continued until the 7th week of the experiment (P=0.007). Optical density significantly increased in the PANTOPRAZOLE-treated RATS after six weeks.Conclusion: Long term PPI therapy at high doses could lead to osteoporosis and enhanced OTM.

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    • Cite

    APA: Copy

    SHIRAZI, MOHSEN, ALIMORADI, HOUMAN, KHEIRANDISH, YASAMAN, ETEMAD MOGHADAM, SHAHROO, ALAEDDINI, MOJGAN, MEYSAMIE, ALIPASHA, FATAHI MEYBODI, SEYED AMIR REZA, & DEHPOUR, AHMAD REZA. (2014). PANTOPRAZOLE, A PROTON PUMP INHIBITOR, INCREASES ORTHODONTIC TOOTH MOVEMENT IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 448-453. SID. https://sid.ir/paper/645740/en

    Vancouver: Copy

    SHIRAZI MOHSEN, ALIMORADI HOUMAN, KHEIRANDISH YASAMAN, ETEMAD MOGHADAM SHAHROO, ALAEDDINI MOJGAN, MEYSAMIE ALIPASHA, FATAHI MEYBODI SEYED AMIR REZA, DEHPOUR AHMAD REZA. PANTOPRAZOLE, A PROTON PUMP INHIBITOR, INCREASES ORTHODONTIC TOOTH MOVEMENT IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(6):448-453. Available from: https://sid.ir/paper/645740/en

    IEEE: Copy

    MOHSEN SHIRAZI, HOUMAN ALIMORADI, YASAMAN KHEIRANDISH, SHAHROO ETEMAD MOGHADAM, MOJGAN ALAEDDINI, ALIPASHA MEYSAMIE, SEYED AMIR REZA FATAHI MEYBODI, and AHMAD REZA DEHPOUR, “PANTOPRAZOLE, A PROTON PUMP INHIBITOR, INCREASES ORTHODONTIC TOOTH MOVEMENT IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 6, pp. 448–453, 2014, [Online]. Available: https://sid.ir/paper/645740/en

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