STEREOLOGICAL ANALYSIS OF CORNU AMMONIS IN PRENATALLY STRESSED RATS: A HEURISTIC NEURODEVELOPMENTAL MODEL OF SCHIZOPHRENIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINI SHARIFABAD MOHAMMAD; SABAHI ABDOREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:3 Page(s): 189-195

Download Full-Text

View:

339

Download:

363

Cites:

Information Journal Paper

Title

STEREOLOGICAL ANALYSIS OF CORNU AMMONIS IN PRENATALLY STRESSED RATS: A HEURISTIC NEURODEVELOPMENTAL MODEL OF SCHIZOPHRENIA

Author(s)

HOSSEINI SHARIFABAD MOHAMMAD | SABAHI ABDOREZA | Issue Writer Certificate

Keywords

CORNU AMMONIS

HIPPOCAMPUS

PRENATAL STRESS

STEREOLOGY

Abstract

Objective (s): The HIPPOCAMPUS has been implicated in pathophysiology of schizophrenia. PRENATAL STRESS is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. This study examined long-term effects of prenatal restraint stress on the stereological parameters in the CORNU AMMONIS (CA) of adult male rats as an animal model of schizophrenia.Materials and Methods: Wistar pregnant dams in experimental group were stressed in a cylindrical Plexiglas restrainer daily for 1 hr during last week of gestation. Controls remained in the animal room and were exposed only to normal animal room conditions. At 2 months of age, the volume of the pyramidal cell layer of the CA, the numerical density and the somal volume of the respective neurons were assessed in the male offspring generated from stressed and control pregnancies. Cavalieri's principle, physical disector and nucleator were applied for stereological analyses.Results: This study showed that PRENATAL STRESS significantly decreased the volume of CA3 pyramidal cell layer and the individual somal volume of CA3 pyramidal neurons. However, there were no markedly differences in the numerical density, total number of CA3 pyramidal neurons and stereological parameters in CA1 of prenatally stressed and control animals.Conclusion: These data indicate that PRENATAL STRESS exposure induced neuronal changes in the CA3 subfield of HIPPOCAMPUS which are similar to what is observed in schizophrenia.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINI SHARIFABAD, MOHAMMAD, & SABAHI, ABDOREZA. (2014). STEREOLOGICAL ANALYSIS OF CORNU AMMONIS IN PRENATALLY STRESSED RATS: A HEURISTIC NEURODEVELOPMENTAL MODEL OF SCHIZOPHRENIA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(3), 189-195. SID. https://sid.ir/paper/645751/en

Vancouver: Copy

HOSSEINI SHARIFABAD MOHAMMAD, SABAHI ABDOREZA. STEREOLOGICAL ANALYSIS OF CORNU AMMONIS IN PRENATALLY STRESSED RATS: A HEURISTIC NEURODEVELOPMENTAL MODEL OF SCHIZOPHRENIA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(3):189-195. Available from: https://sid.ir/paper/645751/en

IEEE: Copy

MOHAMMAD HOSSEINI SHARIFABAD, and ABDOREZA SABAHI, “STEREOLOGICAL ANALYSIS OF CORNU AMMONIS IN PRENATALLY STRESSED RATS: A HEURISTIC NEURODEVELOPMENTAL MODEL OF SCHIZOPHRENIA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 3, pp. 189–195, 2014, [Online]. Available: https://sid.ir/paper/645751/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops