EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN

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MOHAMMADI KARAKANI ALI; ASGHARZADEH HAGHIGHI SOLMAZ; GHAZI KHANSARI MAHMOUD; SEYED EBRAHIMI AFSANEH; ZEIGHAMI MOHAMMADI SHARAREH

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:5 Page(s): 391-395

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Title

EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN

Author(s)

Keywords

BIOMARKER

GENTAMICIN

NEWBORN

URINE

Abstract

Objective (s): In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific BIOMARKERs. We examined the practical applicability of the urinary levels of NAG (N-acetyl-b-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening BIOMARKERs in full and pre-term NEWBORNs treated with GENTAMICIN.Materials and Methods: Fourteen pre-term and fifteen full-term NEWBORNs who received GENTAMICIN for suspected infections were enrolled. Serum and URINE specimens were obtained before the zero days and after GENTAMICIN infusion on the 1st, 3rd, and 5th days of treatment.Results: In full-term NEWBORNs a significant increase in urinary NAG, LDH, AP after 5 days of GENTAMICIN administration compared with control group was noted (P<0.05, P<0.001 and P<0.01; respectively).Conclusion: Our findings indicate that urinary enzymes may be useful in full-term NEWBORNs as a non-invasive method for evaluation of tubular function.

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APA: Copy

MOHAMMADI KARAKANI, ALI, ASGHARZADEH HAGHIGHI, SOLMAZ, GHAZI KHANSARI, MAHMOUD, SEYED EBRAHIMI, AFSANEH, & ZEIGHAMI MOHAMMADI, SHARAREH. (2014). EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(5), 391-395. SID. https://sid.ir/paper/645753/en

Vancouver: Copy

MOHAMMADI KARAKANI ALI, ASGHARZADEH HAGHIGHI SOLMAZ, GHAZI KHANSARI MAHMOUD, SEYED EBRAHIMI AFSANEH, ZEIGHAMI MOHAMMADI SHARAREH. EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(5):391-395. Available from: https://sid.ir/paper/645753/en

IEEE: Copy

ALI MOHAMMADI KARAKANI, SOLMAZ ASGHARZADEH HAGHIGHI, MAHMOUD GHAZI KHANSARI, AFSANEH SEYED EBRAHIMI, and SHARAREH ZEIGHAMI MOHAMMADI, “EVALUATION OF URINARY ENZYMES IN NEWBORNS TREATED WITH GENTAMICIN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 5, pp. 391–395, 2014, [Online]. Available: https://sid.ir/paper/645753/en

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