STUDY OF VITAMIN D RECEPTOR GENE TAQI POLYMORPHISM AND ITS ASSOCIATION WITH LEVELS OF GONADOTROPINS AND STEROID HORMONES BETWEEN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME AND OBESE WOMEN IN CONTROL GROUP

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TAVAKKOLI MINA; OSTADSHARIF MARYAM; NAYERI HASHEM

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2018 | Volume:21 | Issue:8 Page(s): 94-102

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Title

STUDY OF VITAMIN D RECEPTOR GENE TAQI POLYMORPHISM AND ITS ASSOCIATION WITH LEVELS OF GONADOTROPINS AND STEROID HORMONES BETWEEN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME AND OBESE WOMEN IN CONTROL GROUP

Author(s)

TAVAKKOLI MINA | OSTADSHARIF MARYAM | NAYERI HASHEM | Issue Writer Certificate

Keywords

VITAMIN D RECEPTORQ2

POLYCYSTIC OVARY SYNDROMEQ1

STEROID HORMONESQ1

GONADOTROPINSQ1

Abstract

IntroductionPolycystic ovary syndrome (PCOS) is one of the most common disorder of women at reproductive age. Many findings indicate that genetic variations in the VITAMIN D RECEPTOR gene may affect PCOS development. This study was performed with aim to evaluate the associations between TaqI polymorphism in the VITAMIN D RECEPTOR gene (VDR) and PCOS, and the association of TaqI polymorphism with GONADOTROPINS and STEROID HORMONES parameters in two groups of patients and control. MethodsThis case-control study was performed on 77 women who had referred to fertility and infertility center of Isfahan during three months of summer 2016. 38 obese women with PCOS were selected as patient group and 39 healthy obese women as control group. Serum levels of LH, FSH, testosterone and progesterone were measured by ELISA method. The TaqI polymorphism was genotyped by using PCR-RFLP (restriction fragment length polymorphism) technique. Data was analyzed by SPSS software (version 22) and independent t-test, Mann-Whitney, Kruskal-Wallis, and Chi-square test. P<0. 05 was considered statistically significant. ResultsBased on the results of Chi-square test, no difference was found between T and t alleles and TaqI genotypes in PCOS and control women (p> 0. 05). Serum levels of FSH (p = 0. 012) and testosterone (p = 0. 017) was significantly lower in control group than the patient group. There was no significant difference in serum LH and progesterone between patients and control group (P> 0. 05). Also, the level of LH hormone was significantly higher in TT individuals than that of Tt / tt subjects (p = 0. 01). ConclusionAmong the studied population, there was no significant relationship between tt, Tt and TT genotypes with FSH, testosterone and progesterone hormones. Therefore, it can be concluded that TaqI polymorphism was not associated with the risk of POLYCYSTIC OVARY SYNDROME.

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APA: Copy

TAVAKKOLI, MINA, OSTADSHARIF, MARYAM, & NAYERI, HASHEM. (2018). STUDY OF VITAMIN D RECEPTOR GENE TAQI POLYMORPHISM AND ITS ASSOCIATION WITH LEVELS OF GONADOTROPINS AND STEROID HORMONES BETWEEN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME AND OBESE WOMEN IN CONTROL GROUP. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 21(8 ), 94-102. SID. https://sid.ir/paper/64658/en

Vancouver: Copy

TAVAKKOLI MINA, OSTADSHARIF MARYAM, NAYERI HASHEM. STUDY OF VITAMIN D RECEPTOR GENE TAQI POLYMORPHISM AND ITS ASSOCIATION WITH LEVELS OF GONADOTROPINS AND STEROID HORMONES BETWEEN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME AND OBESE WOMEN IN CONTROL GROUP. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2018;21(8 ):94-102. Available from: https://sid.ir/paper/64658/en

IEEE: Copy

MINA TAVAKKOLI, MARYAM OSTADSHARIF, and HASHEM NAYERI, “STUDY OF VITAMIN D RECEPTOR GENE TAQI POLYMORPHISM AND ITS ASSOCIATION WITH LEVELS OF GONADOTROPINS AND STEROID HORMONES BETWEEN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME AND OBESE WOMEN IN CONTROL GROUP,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 21, no. 8 , pp. 94–102, 2018, [Online]. Available: https://sid.ir/paper/64658/en

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