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Information Journal Paper

Title

INDUCTION AND DETERMINATION OF APOPTOTIC AND NECROTIC CELL DEATH BY CADMIUM CHLORIDE IN TESTIS TISSUE OF MOUSE

Pages

  24-29

Abstract

 Background: CADMIUM chloride which is potentially toxic is currently used in industry.The toxic effects of CADMIUM on testes have been reported to range from APOPTOSIS to NECROSIS, with different effects on fertility. This research aimed to study the effect of different doses of CADMIUM on testicular tissues at acute stage by light and electron microscopy.Methods: CADMIUM chloride was injected into mature Balb/c mice intraperitoneally in 7 doses. Five mice were studied in each group. After 48hr, the testes were extracted and prepared for light microscopy. Then two concentrations (15 and 25mM/kg) of them were selected for electron microscopic study based on histological changes.The cellular changes of luminal epithelium of SEMINIFEROUS TUBULES were studied under an electron microscope. Histological and ultrastructural changes were reported.Results: The absence of sperm in the tubules was observed at 20 mM/kg concentration.At 25mM/kg, histological destruction and epithelial damages were observed. Histological changes were not remarkable at 5 and 10mM/kg. However, ultrastructural changes of SEMINIFEROUS TUBULES at 20mM/kg included spermatogonial cell death. At 25mM/kg, vacuolation of Sertoli cells and death of spermatids as well as spermatocytes were observed. Cell death in the tubules was limited to germ cells. However, Sertoli cells exhibited architectural alterations without any cell death.Conclusion: Both APOPTOSIS and NECROSIS occurred in testicular tissue by exposure to CADMIUM in a concentration-dependent manner. Gonadal cells were sensitive to CADMIUM administration. Supportive cells such as Sertoli cells in SEMINIFEROUS TUBULES did not exhibit sensitivity to CADMIUM.

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    APA: Copy

    NIKNAFS, BEHROOZ, SALEHNIA, MOJDEH, & KAMKAR, MAHMOOD. (2015). INDUCTION AND DETERMINATION OF APOPTOTIC AND NECROTIC CELL DEATH BY CADMIUM CHLORIDE IN TESTIS TISSUE OF MOUSE. JOURNAL OF REPRODUCTION AND INFERTILITY, 16(1), 24-29. SID. https://sid.ir/paper/646679/en

    Vancouver: Copy

    NIKNAFS BEHROOZ, SALEHNIA MOJDEH, KAMKAR MAHMOOD. INDUCTION AND DETERMINATION OF APOPTOTIC AND NECROTIC CELL DEATH BY CADMIUM CHLORIDE IN TESTIS TISSUE OF MOUSE. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2015;16(1):24-29. Available from: https://sid.ir/paper/646679/en

    IEEE: Copy

    BEHROOZ NIKNAFS, MOJDEH SALEHNIA, and MAHMOOD KAMKAR, “INDUCTION AND DETERMINATION OF APOPTOTIC AND NECROTIC CELL DEATH BY CADMIUM CHLORIDE IN TESTIS TISSUE OF MOUSE,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 16, no. 1, pp. 24–29, 2015, [Online]. Available: https://sid.ir/paper/646679/en

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